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NativeExtract™ Biotinylated Recombiant Human GCGR Membrane Protein (Full length, Super Nanodisc) (CAT#: SYF-0826-CW28)

This product is biotinylated recombinant Human GCGR protein in native nanodisc form. The synthetic compound we developed can solubilize the GCGR protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • GCGR
  • Protein Length
  • Full length
  • Protein Class
  • GPCR
  • Molecular Weight
  • 54.0 kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • C-terminal FLAG & Avi Tag
  • Protein Format
  • Nanodisc
  • Reconstitution
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • GCGR
  • Full Name
  • Glucagon receptor
  • Introduction
  • Human GCGR (glucagon receptor) is a G protein-coupled receptor (GPCR) that binds glucagon and plays a key role in the regulation of glucose homeostasis. Activation of GCGR primarily stimulates Gs-mediated signaling, promoting hepatic glucose production and contributing to the maintenance of blood glucose levels. Dysregulation of GCGR signaling has been associated with metabolic disorders, including type 2 diabetes.
  • Alternative Names
  • GGR; GL-R; glucagon receptor; GCGR; Glucagon receptor

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