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NativeExtract™ Human CLDN18 Membrane Protein (Full length, Super Nanodisc) (CAT#: S01YF-1023-KX483)

Datasheet
This product is recombinant Human CLDN18 protein in native nanodisc form. The synthetic compound we developed can solubilize the CLDN18 protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • CLDN18
  • Protein Length
  • Full length
  • Molecular Weight
  • 27.5 kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • Flag tag at the C-terminus
  • Protein Format
  • Native Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • CLDN18
  • Full Name
  • Claudin 18
  • Introduction
  • This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified.
  • Alternative Names
  • CLDN18; SFTA5; SFTPJ; claudin-18; surfactant associated 5; surfactant associated protein J; surfactant, pulmonary associated protein J; Claudin 18

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