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Norovirus GI.1 Virus-like Particles (NoV GI.1 VLPs) (CAT#: VLP-020YF)

Datasheet
Recombinant Norovirus GI.1 Virus-like Particles (NoV GI.1 VLPs) are produced in Baculovirus/Insect cell expression system, assembled with VP1 structure protein. VLP is mimicking the native 3D structure of viruses which can elicit strong immune responses. However, VLPs lack viral genomic material which makes them non-infectious, unable to replicate and enhance the safety during manufacture and administration. NoV GI.1 VLPs can be used in the development of NoV GI.1 diagnostics and in vaccine development and R&D (including use as an immunogen).

Product Specifications

  • Structural Proteins
  • VP1
  • Expression Systems
  • Baculovirus/Insect cell expression system (please specify if other expression system is needed)
  • Purity
  • >90%
  • Buffer
  • PBS pH7.4
  • Form
  • Liquid
  • Alternative Names
  • Norovirus GI.1 Virus-like Particles; NoV GI.1 VLPs; Norovirus GI.1 Virus; NoV GI.1; VLP; Virus-like particle
  • Storage
  • Store at -80 °C long term. Avoid repeated freeze/thaw cycles.

Virus Background

  • Virus Family
  • Calciviridae
  • Virus Species
  • Norovirus GI.1 Virus
  • Virus Strain
  • Hu/GI.1/CHA6A007/2010/USA
  • Virus Overview
  • Norovirus, also known as NoV, is in the Caliciviridae family. It's non-enveloped, positive-sense, single-stranded RNA virus. Noroviruses can genetically be classified into at least seven different genogroups (GI, GII, GIII, GIV, GV, GVI, and GVII), which can be further divided into different genetic clusters or genotypes. Most noroviruses that infect humans belong to genogroups GI and GII. The variant GII.4 has been identified as the most common cause of Norovirus outbreaks since 2002. The norovirus genome encodes a large polyprotein which is cleaved into six smaller non-structural proteins (NS1/2 to NS7) by the viral 3C-like protease (NS6), a major structural protein (VP1) of about 58~60 kDa and a minor capsid protein (VP2).
    It's a very contagious virus that causes gastroenteritis. People of all ages can get infected and sick with norovirus. The symptoms of norovirus infection include nausea, vomiting, stomach pain or cramps, watery or loose diarrhea, feeling ill, low-grade fever, muscle pain. Most noroviruses that infect humans belong to genogroups GI and GII.
    The NoV infection can be confirmed by laboratory testing such as virus isolation, RT-PCR, and serology.
  • Virus Structure
  • Non-enveloped, positive-sense, single-stranded RNA virus
  • Related Disease
  • Gastroenteritis

Case Studies

Customer reviews and Q&As    

Customer Review

Passed the ELISA kit)

The ELISA test results with NoV GI.1 VLP as antigen are highly correlated and can be used for serological diagnosis.)
2022-12-19)

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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