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MemDX™ Recombinant Full Length Human ACKR4 Protein (Nanodisc, Rho1D4 Tag & FLAG Tag) (CAT#: SYF-0926-CW32)

Recombinant full-length human ACKR4 protein reconstituted in a nanodisc membrane-mimetic system for biochemical, binding, and assay development applications.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • ACKR4
  • Protein Length
  • Full-length
  • Protein Class
  • GPCR
  • Molecular Weight
  • 41 kDa
  • Sequence
  • ALEQNQSTDYYYEENEMNGTYDYSQYELICIKEDVREFAKVFLPVFLTIVFVIGLAGNSMVVAIYAYYKKQRTKTDVYILNLAVADLLLLFTLPFWAVNAVHGWVLGKIMCKITSALYTLNFVSGMQFLACISIDRYVAVTKVPSQSGVGKPCWIICFCVWMAAILLSIPQLVFYTVNDNARCIPIFPRYLGTSMKALIQMLEICIGFVVPFLIMGVCYFITARTLMKMPNIKISRPLKVLLTVVIVFIVTQLPYNIVKFCRAIDIIYSLITSCNMSKRMDIAIQVTESIALFHSCLNPILYVFMGASFKNYVMKVAKKYGSWRRQRQSVEEFPFDSEGPTEPTSTFSI

Product Description

  • Expression Systems
  • Trichoplusia ni insect cells
  • Tag
  • The construct includes an N-terminal FLAG tag and a C-terminal Rho1D4 tag.
  • Protein Format
  • Nanodisc
  • Purity
  • The protein purity is greater than 90% as determined by SDS-PAGE.

Target

  • Target Protein
  • ACKR4
  • Full Name
  • atypical chemokine receptor 4
  • Introduction
  • Atypical chemokine receptor 4 (ACKR4) is a full-length human gpcr. Atypical Chemokine Receptor 4 (ACKR4) acts as a scavenger that internalizes and degrades homeostatic chemokines (CCL19, CCL21, CCL25, and CCL20), thereby generating the precise directional gradients necessary for proper immune cell trafficking into lymph nodes. Because it controls the spatial positioning of T cells and dendritic cells, modulating ACKR4 is a high-priority strategy to either rescue defective anti-tumor immunity in checkpoint-resistant cancers or mitigate unchecked leukocyte recruitment in inflammatory diseases. The protein is supplied in an MSP-free, copolymer-stabilized native-lipid nanodisc. The preparation uses 2-step purification.
  • Alternative Names
  • CCR11, CCBP2, VSHK1, CCX-CKR, PPR1, CCRL1

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