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MemDX™ Recombinant Full Length Human ADRB2 Protein (Biotinylated Nanodisc, Rho1D4 Tag & FLAG Tag) (CAT#: SYF-0926-CW37)

Recombinant full-length human ADRB2 protein reconstituted in a biotinylated nanodisc membrane-mimetic system for immobilization, binding, detection, and assay development applications; the copolymer is biotinylated while the protein itself remains unmodified.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • ADRB2
  • Protein Length
  • Full-length
  • Protein Class
  • GPCR
  • Molecular Weight
  • 46 kDa
  • Sequence
  • GQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL

Product Description

  • Expression Systems
  • Trichoplusia ni insect cells
  • Tag
  • The construct includes an N-terminal FLAG tag and HRV cleavage site, together with a C-terminal Rho1D4 tag. The copolymer is biotinylated; the protein itself is unmodified.
  • Protein Format
  • Nanodisc
  • Purity
  • The protein purity is greater than 90% as determined by SDS-PAGE.

Target

  • Target Protein
  • ADRB2
  • Full Name
  • adrenoceptor beta 2
  • Introduction
  • Beta-2 adrenergic receptor (ADRB2) is a full-length human gpcr. Beta-2 adrenergic receptor, commonly known as ADRB2, is part of a receptor channel complex comprised of a G protein, an adenylyl cyclase, a cAMP-dependent kinase and a counterbalancing phosphatase, PP2A. ADRB2 is involved in the mediation of physiological responses including the smooth muscle relaxation and it is also targeted for treatment of asthma and COPD. The surrounding nanodisc copolymer is biotinylated to support direct surface immobilization without modifying the protein itself. The preparation uses 2-step purification.
  • Alternative Names
  • ADRBR, BAR, B2AR, ARB2, ADRB2R

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