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MemDX™ Recombinant Full Length Human CLRN1/USH3A Protein (Nanodisc, Rho1D4 Tag) (CAT#: SYF-0926-CW105)

Recombinant full-length human CLRN1/USH3A protein reconstituted in a nanodisc membrane-mimetic system for biochemical, binding, and assay development applications.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • CLRN1/USH3A
  • Protein Length
  • Full-length
  • Protein Class
  • Clarin Family Membrane Protein
  • Molecular Weight
  • 27 kDa
  • Sequence
  • MPSQQKKIIFCMAGVFSFACALGVVTALGTPLWIKATVLCKTGALLVNASGQELDKFMGEMQYGLFHGEGVRQCGLGARPFRFSFFPDLLKAIPVSIHVNVILFSAILIVLTMVGTAFFMYNAFGKPFETLHGPLGLYLLSFISGSCGCLVMILFASEVKIHHLSEKIANYKEGTYVYKTQSEKYTTSFWVIFFCFFVHFLNGLLIRLAGFQFPFAKSKDAETTNVAADLMY

Product Description

  • Expression Systems
  • HEK293 cells
  • Tag
  • The construct includes a C-terminal Rho1D4 tag.
  • Protein Format
  • Nanodisc
  • Purity
  • The protein purity is greater than 90% as determined by SDS-PAGE.

Target

  • Target Protein
  • CLRN1/USH3A
  • Full Name
  • clarin 1
  • Introduction
  • Clarin-1 (CLRN1/USH3A) is a full-length human transporter. Clarin-1 is a protein that plays a role in the development and homeostasis of the inner ear and retina, and in vision and hearing in general. It is also involved in the development of synapses, which allow cell-cell communication. Mutations in CLRN1 have been associated with several diseases that affect hearing or vision, such as retinitis pigmentosa and Usher syndrome type 3a. The protein is supplied in an MSP-free, copolymer-stabilized native-lipid nanodisc. The preparation uses 2-step purification.
  • Alternative Names
  • USH3, USH3A, RP61

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