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NativeExtract™ Recombinant Full Length Human GRID2 Protein (Nanodisc, FLAG- & Strep-tagged) (CAT#: SYF-0426-CW87)

Datasheet
This product is recombinant Human GRID2 protein in native nanodisc form. The synthetic compound we developed can solubilize the GRID2 protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • GRID2
  • Protein Length
  • Full length
  • Protein Class
  • Ion Channel
  • Molecular Weight
  • 113.4 kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • The recombinant protein is constructed with FLAG Tag & Strep Tag at C-terminus.
  • Protein Format
  • Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • GRID2
  • Full Name
  • Glutamate Ionotropic Receptor Delta Type Subunit 2
  • Introduction
  • The protein encoded by this gene is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause cerebellar ataxia in humans.
  • Alternative Names
  • Glutamate Ionotropic Receptor Delta Type Subunit 2; Glutamate Receptor, Ionotropic, Delta 2; GluR Delta-2 Subunit; GluD2; Glutamate Receptor Ionotropic, Delta-2; Glutamate Receptor Delta-2 Subunit; SCAR18; GLURD2

Case Studies

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