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NativeExtract™ Recombinant Biotinylated Full Length Human CCR2 Protein (Petitide Nanodisc, FLAG- & Avi-tagged) (CAT#: SYF-0426-CW313)

Datasheet
This product is recombinant biotinylated full length Human CCR2 protein in peptide nanodisc form. The synthetic peptide scaffold we developed can extract and stabilize the CCR2 protein while preserving its native conformation.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • CCR2
  • Protein Length
  • Full length
  • Protein Class
  • GPCR; Checkpoint
  • Molecular Weight
  • 41.9 kDa
  • Sequence
  • Our product features full-length membrane proteins with complete, native sequences, ensuring optimal structural integrity and functional activity for your research needs.

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • The recombinant protein is constructed with FLAG Tag & Avi Tag at C-terminus.
  • Protein Format
  • Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • CCR2
  • Full Name
  • C-C motif chemokine receptor 2
  • Introduction
  • CCR2 (C-C chemokine receptor type 2) is a member of the G protein-coupled receptor family. It plays a crucial role in immune cell migration by binding to specific chemokines, primarily CCL2, CCL7, and CCL8. CCR2 is involved in the recruitment of monocytes, dendritic cells, and other immune cells to sites of inflammation, which makes it a key player in inflammatory responses and immune regulation. It is highly expressed in various tissues, including the bone marrow, spleen, and peripheral blood monocytes. CCR2 has been implicated in several pathological conditions, including atherosclerosis, rheumatoid arthritis, and multiple sclerosis. Studies suggest that CCR2 inhibition can help reduce inflammation and may be a potential therapeutic target for inflammatory diseases.
  • Alternative Names
  • CKR2; CCR-2; CCR2A; CCR2B; CD192; CKR2A; CKR2B; PCLUD; CMKBR2; MCP-1-R; CC-CKR-2

Case Studies

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