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MemDX™ Recombinant Full Length Human HTR7 Protein (Biotinylated Nanodisc, Rho1D4 Tag & FLAG Tag) (CAT#: SYF-0926-CW130)

Datasheet
Recombinant full-length human HTR7 protein reconstituted in a biotinylated nanodisc membrane-mimetic system for immobilization, binding, detection, and assay development applications; the copolymer is biotinylated while the protein itself remains unmodified.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • HTR7
  • Protein Length
  • Full-length
  • Protein Class
  • GPCR
  • Molecular Weight
  • 55 kDa
  • Sequence
  • MDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD

Product Description

  • Expression Systems
  • Trichoplusia ni insect cells
  • Tag
  • The construct includes an N-terminal HA signal peptide and FLAG tag, together with a C-terminal Rho1D4 tag. The copolymer is biotinylated; the protein itself is unmodified.
  • Protein Format
  • Nanodisc
  • Purity
  • The protein purity is greater than 90% as determined by SDS-PAGE.

Target

  • Target Protein
  • HTR7
  • Full Name
  • 5-hydroxytryptamine receptor 7
  • Introduction
  • 5-hydroxytryptamine receptor 7 (HTR7) is a full-length human gpcr. The HTR7 gene encodes the 5-HT7 receptor, a G-protein-coupled receptor that regulates cyclic AMP signaling to modulate neuroplasticity, circadian rhythms, cognition, and smooth muscle relaxation. Consequently, blocking this receptor is a proven strategy for treating major depression and schizophrenia, while activating it shows therapeutic potential for addressing neurodevelopmental and sleep disorders. The surrounding nanodisc copolymer is biotinylated to support direct surface immobilization without modifying the protein itself. The preparation uses 2-step purification.
  • Alternative Names
  • 5-HT7

Case Studies

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