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Recombinant Human CGRPR-RAMP1 Full-Length Membrane Protein, MNP (CAT#: SYF-0826-CW27)

This product contains recombinant full-length human CGRPR (CALCRL)-RAMP1 Complex expressed in HEK293 cells and presented in a membrane nanoparticle format with a C-terminal Flag tag.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • CGRPR-RAMP1
  • Protein Length
  • CALCRL: 461 aa; RAMP1: 148 aa
  • Protein Class
  • Class B GPCR-receptor activity-modifying protein complex
  • Molecular Weight
  • 53.0 kDa
  • TMD
  • 7; 1

Product Description

  • Activity
  • Validated by ELISA; antibody-binding EC50: 122.8 ng/mL.
  • Application
  • ELISA; Antibody binding and screening studies
  • Expression Systems
  • HEK293 expression system
  • Tag
  • C-Terminal Flag Tag
  • Protein Format
  • Membrane Nanoparticle (MNP)
  • Buffer
  • PBS, pH 7.4, with 5-8% trehalose as a lyoprotectant

Target

  • Target Protein
  • CGRPR-RAMP1
  • Full Name
  • calcitonin receptor like receptor and receptor activity modifying protein 1
  • Introduction
  • The functional CGRP receptor is formed by CALCRL together with RAMP1. This heteromeric receptor binds calcitonin gene-related peptide and activates Gs-dependent signaling pathways implicated in migraine and vascular biology.
  • Alternative Names
  • CALCRL; CRLR; LMPHM8

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