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MemDX™ Recombinant Full Length Human OPRM1 Protein (Biotinylated Nanodisc, Rho1D4 Tag & FLAG Tag) (CAT#: SYF-0926-CW148)

Datasheet
Recombinant full-length human OPRM1 protein reconstituted in a biotinylated nanodisc membrane-mimetic system for immobilization, binding, detection, and assay development applications; the copolymer is biotinylated while the protein itself remains unmodified.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • OPRM1
  • Protein Length
  • Full-length
  • Protein Class
  • GPCR
  • Molecular Weight
  • 47 kDa
  • Sequence
  • DSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP

Product Description

  • Expression Systems
  • Trichoplusia ni insect cells
  • Tag
  • The construct includes an N-terminal FLAG tag and a C-terminal Rho1D4 tag. The copolymer is biotinylated; the protein itself is unmodified.
  • Protein Format
  • Nanodisc
  • Purity
  • The protein purity is greater than 90% as determined by SDS-PAGE.

Target

  • Target Protein
  • OPRM1
  • Full Name
  • opioid receptor mu 1
  • Introduction
  • Mu-type opioid receptor (OPRM1) is a full-length human gpcr. G-protein coupled opioid receptor that functions as a primary receptor for endogenous beta-endorphins and enkephalins, but has lower affinity for dynorphins. It also functions as the principal receptor for various synthetic opioids (such as morphine, fentanyl, and oxycodone) and for the competitive antagonist naloxone. Beyond analgesia, it play a critical role in regulating autonomic and physical functions, including the modulation of respiratory rate, gastrointestinal motility, and the neuroendocrine stress response. The surrounding nanodisc copolymer is biotinylated to support direct surface immobilization without modifying the protein itself. The preparation uses 2-step purification.
  • Alternative Names
  • MOR1, MOP

Case Studies

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