Introduction of RXFP3
Relaxin-3 Receptor 1 (RXFP3) is encoded by the RXFP3 gene. It belongs to the G-protein-coupled receptor (GPCR) family which has been extensively studied during the past few decades because it offers numerous possibilities for therapeutic applications. Relaxin is a hormone which was first discovered to play a role in pregnancy. Recent researches found that it is also a cardiovascular protector. Studies have identified four receptors that are the physiological targets for relaxin family peptides. They are therefore named RXFP1-4 (relaxin family peptide receptors1-4). RXFP3 belongs to type 1 small peptide receptors and its structural feature is a relatively short N-terminal domain.
|Basic Information of RXFP3|
|Protein Name||Relaxin-3 receptor 1|
|Aliases||RLN3R1, SALPR, GPCR135|
|Organism||Homo sapiens (Human)|
Function of RXFP3 Membrane Protein
RXFP3 is a receptor for RNL3/relaxin-3. Binding of the ligand inhibits cAMP accumulation. The main ligand of RXFP3 is relaxin-3. The current study considers that Relaxin-3 is a neurohormone and the relaxin-3-RXFP3 system mainly plays a regulatory role in the central nervous system and it participates in the regulation of response, maintenance of arousal and cognitive function. Besides, cell signaling events associated with the relaxin-family receptors have been researched in different cell lines transfected with the human receptors and activation of RXFP1 and RXFP3/4 by H3 relaxin results in different intracellular responses in vitro. It has reported that in CHO cells, RXFP3 and RXFP4 couple to the inhibitory Gαi/Gαo-protein system and receptor activation results in sequestration of these G-proteins and inhibition of adenylate cyclase (AC), and subsequent cAMP accumulation.
Fig.1 Distribution of the relaxin-3 neural network and RXFP3 in relation to RXFP1, illustrated on a schematic parasagittal profile of the rodent brain.
Application of RXFP3 Membrane Protein in Literature
This article reports that the distribution of RLN3/RXFP3 networks in rat brain and recent experimental studies suggest a role for this system in modulation of arousal, stress, metabolism, and cognition.
This article reveals that neuroanatomical colocalization of GPCR135 and relaxin-3, coupled with a clear high-affinity interaction, suggest that GPCR135 is the receptor for relaxin-3.
This study demonstrates that the A-chains among some of the insulin/relaxin family members are pharmacologically exchangeable.
The results of this experiment provide new insights into the action of relaxing and demonstrate that the role of the A-chain for relaxin activity is both peptide- and receptor-dependent.
RXFP3 Preparation Options
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