RXFP3 Membrane Protein Introduction

Introduction of RXFP3

Relaxin-3 Receptor 1 (RXFP3) is encoded by the RXFP3 gene. It belongs to the G-protein-coupled receptor (GPCR) family which has been extensively studied during the past few decades because it offers numerous possibilities for therapeutic applications. Relaxin is a hormone which was first discovered to play a role in pregnancy. Recent researches found that it is also a cardiovascular protector. Studies have identified four receptors that are the physiological targets for relaxin family peptides. They are therefore named RXFP1-4 (relaxin family peptide receptors1-4). RXFP3 belongs to type 1 small peptide receptors and its structural feature is a relatively short N-terminal domain.

Basic Information of RXFP3
Protein Name Relaxin-3 receptor 1
Gene Name RXFP3
Aliases RLN3R1, SALPR, GPCR135
Organism Homo sapiens (Human)
UniProt ID Q9NSD7
Transmembrane Times 7
Length (aa) 469

Function of RXFP3 Membrane Protein

RXFP3 is a receptor for RNL3/relaxin-3. Binding of the ligand inhibits cAMP accumulation. The main ligand of RXFP3 is relaxin-3. The current study considers that Relaxin-3 is a neurohormone and the relaxin-3-RXFP3 system mainly plays a regulatory role in the central nervous system and it participates in the regulation of response, maintenance of arousal and cognitive function. Besides, cell signaling events associated with the relaxin-family receptors have been researched in different cell lines transfected with the human receptors and activation of RXFP1 and RXFP3/4 by H3 relaxin results in different intracellular responses in vitro. It has reported that in CHO cells, RXFP3 and RXFP4 couple to the inhibitory Gαi/Gαo-protein system and receptor activation results in sequestration of these G-proteins and inhibition of adenylate cyclase (AC), and subsequent cAMP accumulation.

Distribution of the relaxin-3 neural network and RXFP3 in relation to RXFP1, illustrated on a schematic parasagittal profile of the rodent brain. Fig.1 Distribution of the relaxin-3 neural network and RXFP3 in relation to RXFP1, illustrated on a schematic parasagittal profile of the rodent brain.

Application of RXFP3 Membrane Protein in Literature

  1. Smith C.M., et al. Distribution of relaxin-3 and RXFP3 within arousal, stress, affective, and cognitive circuits of mouse brain. Comp Neurol. 2010, 518(19): 4016-45. PubMed ID: 20737598

    This article reports that the distribution of RLN3/RXFP3 networks in rat brain and recent experimental studies suggest a role for this system in modulation of arousal, stress, metabolism, and cognition.

  2. Liu C., et al. Identification of relaxin-3/INSL7 as an endogenous ligand for the orphan G-protein-coupled receptor GPCR135. biol chem. 2003, 278(50): 50753-64. PubMed ID: 14522968

    This article reveals that neuroanatomical colocalization of GPCR135 and relaxin-3, coupled with a clear high-affinity interaction, suggest that GPCR135 is the receptor for relaxin-3.

  3. Liu C., et al. Relaxin-3/insulin-like peptide 5 chimeric peptide, a selective ligand for G protein-coupled receptor (GPCR)135 and GPCR142 over leucine-rich repeat-containing G protein-coupled receptor 7. Mol pharmacol. 2005, 67(1): 231-40. PubMed ID: 15465925

    This study demonstrates that the A-chains among some of the insulin/relaxin family members are pharmacologically exchangeable.

  4. Hossain M.A., et al. The A-chain of human relaxin family peptides has distinct roles in the binding and activation of the different relaxin family peptide receptors. biol chem. 2008, 283(25): 17287-97. PubMed ID: 18434306

    The results of this experiment provide new insights into the action of relaxing and demonstrate that the role of the A-chain for relaxin activity is both peptide- and receptor-dependent.

RXFP3 Preparation Options

To obtain the soluble and functional target protein, the versatile Magic™ membrane protein production platform in Creative Biolabs enables many flexible options, from which you can always find a better match for your particular project. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-RXFP3 antibody development services.

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All listed customized services & products are for research use only, not intended for pharmaceutical, diagnostic, therapeutic or any in vivo human use.

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