SV2B Membrane Protein Introduction

Introduction of SV2B

Synaptic vesicle glycoprotein 2B is a protein that in humans is encoded by the SV2B gene, which is mapped to the chromosome 15q26.1. SV2s are hydrophobic proteins with 12 potential transmembrane regions and a cytoplasmic N- and C-terminus, amongst, the N terminus of SV2s contains a long sequence that varies among the three SV2 proteins but includes a short-conserved region which reacts with the monoclonal SV2 antibody in all three SV2s.

Basic Information of SV2B
Protein Name	Synaptic vesicle glycoprotein 2B
Gene Name	SV2B
Aliases	KIAA0735
Organism	Homo sapiens (Human)
UniProt ID	Q7L1I2
Transmembrane Times	12
Length (aa)	683
Sequence	MDDYKYQDNYGGYAPSDGYYRGNESNPEEDAQSDVTEGHDEEDEIYEGEYQGIPHPDDVKAKQAKMAPSRMDSLRGQTDLMAERLEDEEQLAHQYETIMDECGHGRFQWILFFVLGLALMADGVEVFVVSFALPSAEKDMCLSSSKKGMLGMIVYLGMMAGAFILGGLADKLGRKRVLSMSLAVNASFASLSSFVQGYGAFLFCRLISGIGIGGALPIVFAYFSEFLSREKRGEHLSWLGIFWMTGGLYASAMAWSIIPHYGWGFSMGTNYHFHSWRVFVIVCALPCTVSMVALKFMPESPRFLLEMGKHDEAWMILKQVHDTNMRAKGTPEKVFTVSNIKTPKQMDEFIEIQSSTGTWYQRWLVRFKTIFKQVWDNALYCVMGPYRMNTLILAVVWFAMAFSYYGLTVWFPDMIRYFQDEEYKSKMKVFFGEHVYGATINFTMENQIHQHGKLVNDKFTRMYFKHVLFEDTFFDECYFEDVTSTDTYFKNCTIESTIFYNTDLYEHKFINCRFINSTFLEQKEGCHMDLEQDNDFLIYLVSFLGSLSVLPGNIISALLMDRIGRLKMIGGSMLISAVCCFFLFFGNSESAMIGWQCLFCGTSIAAWNALDVITVELYPTNQRATAFGILNGLCKFGAILGNTIFASFVGITKVVPILLAAASLVGGGLIALRLPETREQVLM

Function of SV2B Membrane Protein

SV2 proteins may modulate synaptic vesicle exocytosis through direct interaction with synaptotagmin 1. SV2B is mainly released in neurotransmitters due to its involvement in the regulation of synaptic vesicles and extracellular secretion, which is widely distributed in the brain. In contrast to SV2A and SV2C, SV2B lacks a significant portion of the cytoplasm, so it can regulate protein interactions. SV2B also lacks regions of the large lumenal domain between transmembrane domains 7 and 8 that are present in SV2A and SV2C. The decrease of SV2B mRNA was already detected before the onset of proteinuria in puromycin aminonucleoside nephropathy (PAN). The mRNA expression of SV2B clearly is altered not only in PAN but also in another proteinuric state that is caused by an antibody against nephrin.

Fig.1 Presynaptic vesicle fusion machinery. (Li, 2017)

Application of SV2B Membrane Protein in Literature

Fukusumi Y., et al. SV2B is essential for the integrity of the glomerular filtration barrier. Lab Invest. 2015, 95(5): 534-545. PubMed ID: 25730372

This article shows that SV2B has an essential role in the formation and maintenance of the glomerular capillary wall.
Detrait E., et al. Lack of synaptic vesicle protein SV2B protects against amyloid-β_25-35-induced oxidative stress, cholinergic deficit and cognitive impairment in mice. Behav Brain Res. 2014, 271: 277-285. PubMed ID: 24937053

This article reveals that SV2B could be a key modulator of amyloid toxicity at the synaptic site.
Giguère A., et al. Identification of a novel fusion gene involving RUNX1 and the antisense strand of SV2B in a BCR-ABL1-positive acute leukemia. Genes Chromosomes Cancer. 2013, 52(12): 1114-1122. PubMed ID: 24123676

This article suggests that the rearrangement produces a fusion of the RUNX1 and SV2B gene antisense strands, a novel translocation partner of RUNX1, which produces an out-of-frame mRNA chimeric transcript and putative truncated RUNX1 forms.
Crèvecœur J., et al. Expression of SV2 isoforms during rodent brain development. BMC Neurosci. 2013, 14: 87. PubMed ID: 23937191

The authors find that the increase of SV2A expression in the hippocampus at P7 is mainly observed in the CA1 region while SV2B expression in this region remains stable.
Morgans C.W., et al Loss of the Synaptic Vesicle Protein SV2B results in reduced neurotransmission and altered synaptic vesicle protein expression in the retina. PLoS One. 2009, 4(4): e5230 PubMed ID: 19381277

This article indicates that SV2B helps regulate synaptic vesicles and plays an important role in regulating synaptic protein levels.

SV2B Preparation Options

To obtain the soluble and functional target protein, the versatile Magic™ membrane protein production platform in Creative Biolabs enables many flexible options, from which you can always find a better match for your particular project. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-SV2B antibody development services.

Creative Biolabs' skillful scientists are glad to leverage our expertise and advanced technologies to help you with the member protein research. If you are interested, please feel free to contact us for more details.

Reference

Li Y C, et al. (2017). Synaptic Vesicle-Recycling Machinery Components as Potential Therapeutic Targets. Pharmacological Reviews. 69(2), 141-160.

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