Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
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Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
C-C motif chemokine ligand 1 (CCL1) is a small secreted inflammatory chemokine encoded by CCL1 gene, mainly secreted by activated dendritic cells, cutaneous keratinocytes and tissue-resident macrophages upon allergen stimulation. Distinct from broad-spectrum pro-inflammatory chemokines, CCL1 selectively binds CCR8 receptor expressed exclusively on Th2 lymphocytes and cutaneous regulatory T cells to guide targeted immune cell chemotaxis to inflamed skin and mucosal tissues. Under healthy steady-state immunity, minimal basal CCL1 secretion maintains mild cutaneous immune surveillance without excessive inflammatory infiltration. After allergen exposure or skin barrier damage, CCL1 transcription rises sharply, triggering massive Th2 cell migration to lesion sites and releasing IL-4/IL-13 cytokines that amplify atopic dermatitis, hay fever and asthma symptoms. Its CCR8-specific chemoattractant property cannot be fully substituted by other CC chemokines; neutralizing CCL1 suppresses Th2-driven allergic lesions, while sustained CCL1 overexpression worsens chronic inflammatory skin disorders, making CCL1 an irreplaceable core research target for type 2 immunity and anti-allergy compound screening.
CCL executes secreted soluble chemokine function within tissue interstitial fluid, relying on conserved N-terminal CC chemokine fold to form stable dimers and specifically recognize CCR8 transmembrane receptors on Th2 immune cells. Its narrow cell tropism clearly separates CCL1 from pan-leukocyte chemokines, forming a dedicated signaling axis for type 2 allergic inflammation. CCL1-mediated immune cell trafficking links epithelial allergen sensing to Th2 inflammatory amplification, balancing physiological tissue defense and pathological allergic injury according to barrier integrity status. CCL1 participates in cutaneous atopic inflammation and mucosal allergic airway responses. Loss of functional CCL1 greatly reduces Th2 cell accumulation at inflammatory lesion sites. Therefore, CCL1 represents a pivotal research target for CC chemokine study and atopic disease therapeutic exploration.
Fig. 1 Four-panel cryo-EM crystal schematic showing full Fab-CCR8 complex and zoomed residue-level hydrogen bond interactions between antibody CDR loops and receptor ECL1/ECL2 extracellular loops.1
The biological functions of secreted dimeric CCL1 chemokine are fully focused on specific CCR8 receptor binding and Th2 immune signal amplification:
Creative Biolabs offers high-quality CCL1 proteins through optimized eukaryotic secretion systems, including full-length mature secreted CCL1 and truncated receptor-binding domain variants. These products retain native CCR8 chemoattractant binding activity, suitable for Th2 migration and anti-atopic compound screening assays. All CCL1 proteins undergo strict quality control to ensure consistent performance and reliable application across diverse immunology research platforms.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Creative Biolabs provides custom-engineered CCL1 stable cell lines, including allergen-inducible overexpression and blank empty vector control models. These cell lines are optimized for CC chemokine profiling and Th2 migratory signal functional analysis. Each cell line undergoes stringent validation to ensure stable expression profiles during long-term epithelial cell culture, and can be deployed for large-scale anti-allergy small molecule screening experiments.
Not finding the stable cell line product you need? Contact us to start your one-stop custom service!
High-specificity recombinant antibodies targeting CCL1 are developed via advanced antibody engineering technologies. These antibodies are validated for tissue interstitial chemokine detection and inflamed skin tissue expression profiling, and can be combined with CCR8 detection reagents to analyze complete CCL1-CCR8 immune recruitment complexes in epithelial cell models.
Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!
Beyond catalog products, Creative Biolabs offers specialized custom services for CCL1 research:
CCL1 is a secreted CC chemokine that binds CCR8 to specifically recruit Th2 cells to allergic inflamed tissues.
CCL1 acts as a master mediator of type 2 inflammation, a promising therapeutic target for atopic dermatitis and asthma.
No, all CCL1 products and services are strictly for research use only, not intended for clinical diagnosis or treatment.
Offerings include full-length secreted CCL1 chemokines, isoform-specific detection antibodies and custom stable cell lines for allergic immune research.
CCL1 proteins are validated via CCR8 binding and Th2 chemotaxis functional testing.
