Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
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Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
CD207 molecule (Langerin) is a transmembrane C-type lectin receptor encoded by the CD207 gene, uniquely expressed in epidermal Langerhans dendritic cell subsets, localized to plasma membrane and intracellular Birbeck granule membranes. Distinct from other dendritic cell lectins, CD207 contains calcium-dependent carbohydrate recognition domains that bind glycan moieties on pathogens and particulate antigens, mediating endocytic antigen uptake and specialized Birbeck granule formation for antigen processing pathways. Under steady cutaneous conditions, basal CD207 expression sustains low-level environmental antigen sampling without robust immune activation. Upon cutaneous pathogen or allergen exposure, glycan ligand crosslinking drives CD207 internalization and antigen sorting to processing compartments, facilitating adaptive immune priming in skin-draining lymphoid tissue. Unlike broadly expressed C-type lectins on myeloid cells, CD207 carries Langerhans cell-restricted antigen capture functions that cannot be fully compensated by other lectin family members, linking glycan antigen recognition to skin dendritic cell immune priming pathways. Loss of functional CD207 impairs cutaneous antigen sampling and weakens skin adaptive immune responses, while elevated CD207 expression enhances particulate antigen internalization, establishing CD207 as a core research target for C-type lectin biology and skin immune modulator screening.
CD207 executes calcium-dependent glycan-sensing lectin function embedded within Langerhans cell membrane bilayers, utilizing conserved carbohydrate recognition domains to mediate selective calcium-dependent binding of microbial and environmental glycans. Conserved glycan binding pockets restrict substrate recognition to pathogen surface carbohydrate structures, separating its ligand spectrum from other myeloid C-type lectins. CD207-mediated antigen uptake bridges extracellular cutaneous antigen capture and intracellular antigen processing machinery, balancing dendritic cell antigen sampling intensity relative to environmental stimulus load. CD207 participates in Birbeck granule biogenesis, skin pathogen recognition and naive T cell priming. Deficient CD207 expression disrupts Langerhans cell antigen trafficking and impairs cutaneous immune surveillance. Therefore, CD207 represents a pivotal research target for tissue-restricted C-type lectin study and dermatological immune compound screening.
Fig. 1 Schematic of trimeric CD207 (Langerin)-mediated ligand uptake and intracellular CapG-dependent transcriptional repression of TNFα in dendritic cells.1
The biological functions of CD207 are focused on calcium-mediated glycan ligand binding, endocytic antigen uptake and cutaneous immune control:
Creative Biolabs offers high-quality CD207 proteins through optimized expression systems, including full-length Langerin lectin receptor and isolated carbohydrate recognition domain variants. These products retain native calcium-dependent glycan binding biological activity, suitable for lectin-ligand interaction assays and skin immune modulator screening. All CD207 proteins undergo strict quality control to ensure consistent performance and reliable application across diverse research platforms.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Creative Biolabs provides custom-engineered CD207 stable cell lines, including overexpression and blank control models. These cell lines are optimized for tissue-specific lectin expression profiling and antigen uptake functional analysis. Each cell line undergoes stringent validation to ensure stable expression profiles and consistent functional performance in diverse experimental contexts.
Not finding the stable cell line product you need? Contact us to start your one-stop custom service!
High-specificity recombinant antibodies targeting CD207 are developed via advanced antibody engineering technologies, with no cross-reactivity with other C-type lectin receptors. These antibodies are validated for plasma membrane and Birbeck granule localization detection and epidermal Langerhans cell expression profiling, and can be combined with glycan ligand detection reagents to analyze complete CD207 antigen uptake complexes in dendritic cell models.
Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!
Beyond catalog products, Creative Biolabs offers specialized custom services for CD207 research:
CD207 (Langerin) is a Langerhans cell C-type lectin that binds carbohydrate antigens to mediate endocytic uptake and Birbeck granule formation for skin immune priming.
CD207 acts as a critical link between cutaneous environmental antigen capture and dendritic cell antigen presentation, governing skin adaptive immune surveillance.
No, all CD207 products and services are strictly for research use only, not intended for clinical diagnosis or treatment.
Offerings include full-length CD207 lectin receptors, isoform-specific detection antibodies and custom stable cell lines for epidermal dendritic cell research.
CD207 proteins are validated via calcium-dependent glycan ligand binding functional testing.
