Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
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Cytokine receptor-like factor 2 (CRLF2), encoded by the CRLF2 gene and also known as TSLPR or CRL2, is a member of the type I cytokine receptor family. The CRLF2 gene is located in the pseudoautosomal region of the sex chromosomes at Xp22.3 and Yp11.3, a region where genes encoding the IL-3 receptor alpha and GM-CSF receptor alpha chains are also situated. The deduced amino acid sequence of 371 residues includes a typical signal sequence and a single membrane-spanning region. The mature protein is predicted to have a molecular mass of approximately 39.7 kDa. Structurally, the N-terminal extracellular region contains two fibronectin type III-like domains, four conserved cysteine residues, and a WSXWS box-like motif—all characteristic features of type I cytokine receptor family members. The C-terminal intracellular region contains box 1 and box 2-like motifs that mediate interactions with JAK kinases. CRLF2 is expressed in heart, skeletal muscle, kidney, and adult and fetal liver, and is preferentially expressed in myeloid cells including dendritic cells and monocytes, with weaker expression in T cells. The WSXWS motif appears to be necessary for proper protein folding and efficient intracellular transport.
CRLF2 functions as the receptor subunit for thymic stromal lymphopoietin (TSLP). CRLF2 heterodimerizes with the interleukin-7 receptor alpha chain (IL-7Rα/CD127) to form the heterodimeric thymic stromal lymphopoietin receptor (TSLPR). Binding of TSLP to CRLF2 is a mechanistic prerequisite for recruitment of IL-7Rα to form the high-affinity ternary complex. Formation of this functional receptor complex activates receptor-associated JAK2 and downstream signaling pathways, prominently including STAT3 and STAT5, which contribute to the regulation of cell proliferation and development of the hematopoietic system. Through its participation in the TSLP receptor system, CRLF2 is involved in processes such as hematopoietic cell development, dendritic cell maturation, and immune cell signaling. Its receptor subunit function makes CRLF2 a valuable research target for studies of type I cytokine receptor biology, JAK-STAT signaling, hematopoietic development, and immune regulation.
Fig. 1 Normal activation of CRLF2 occurs upon the binding of thymic stromal lymphopoietin (TSLP), which induces a conformational change resulting in receptor dimerization.1
CRLF2, encoded by the CRLF2 gene, functions as a receptor subunit in the thymic stromal lymphopoietin receptor complex involved in TSLP signaling:
Creative Biolabs offers high-quality CRLF2 membrane protein products produced using optimized expression systems. These include full-length type I transmembrane protein that retains the native membrane-spanning domain and cytoplasmic box 1/box 2 motifs, as well as isolated extracellular domain variants containing the fibronectin type III-like domains and WSXWS box-like motif. The extracellular domains mediate TSLP binding and heterodimer assembly with IL-7Rα, making these proteins suitable for studies of TSLP receptor-ligand interactions, heterodimer formation, and JAK-STAT signaling characterization. All CRLF2 proteins undergo strict quality control to support consistent performance across applicable research platforms.
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Creative Biolabs provides custom-engineered CRLF2 stable cell lines, including overexpression and knockdown models. These cell lines are optimized for studies of TSLP receptor signaling, JAK-STAT pathway activation, and hematopoietic cell development. Each cell line undergoes stringent validation to ensure stable expression profiles and consistent functional performance in diverse experimental contexts.
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High-specificity recombinant antibodies targeting CRLF2 are developed using antibody engineering technologies for research applications involving CRLF2 expression and localization. These antibodies can be used in studies of CRLF2 distribution in relevant cell and tissue models and may also support characterization of CRLF2-containing TSLP receptor complexes in combination with appropriate TSLP, IL-7Rα, or related detection reagents.
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Beyond catalog products, Creative Biolabs offers specialized custom services for CRLF2 research:
