Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
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Interleukin 1 receptor like 1 (IL1RL1), also known as ST2, is a member of the interleukin-1 receptor family and serves as the primary receptor for the alarmin cytokine IL-33. The IL1RL1 gene gives rise to multiple isoforms, most notably the membrane-bound signaling receptor ST2L and the soluble isoform sST2. ST2L is a single-pass transmembrane glycoprotein containing extracellular immunoglobulin-like domains, a transmembrane region, and an intracellular Toll/IL-1 receptor (TIR) domain. It is expressed by a broad range of immune and tissue-resident cell populations involved in type 2 immunity, including group 2 innate lymphoid cells, mast cells, eosinophils, Th2 cells, epithelial cells, and stromal cells. In contrast, sST2 lacks the transmembrane and intracellular signaling regions and functions primarily as a soluble decoy receptor that can sequester IL-33 and limit its availability for ST2L-dependent signaling.
IL1RL1 mediates IL-33 signaling through a stepwise receptor assembly mechanism. IL-33 first binds directly to membrane-bound ST2L, forming an IL-33-ST2L binary complex that subsequently recruits IL-1 receptor accessory protein (IL1RAP/IL-1RAcP) to generate the signaling-competent heterodimeric receptor complex. Juxtaposition of the intracellular TIR domains promotes recruitment of adaptor and signaling proteins, including MyD88, IRAK family kinases, and TRAF6, leading to activation of downstream NF-κB and MAPK pathways and the induction of type 2 inflammatory gene programs. Through this pathway, IL1RL1 regulates alarmin sensing, innate and adaptive type 2 immune responses, mucosal inflammation, tissue repair, and allergic immune activity. The balance between signaling-competent ST2L and soluble sST2 provides an additional level of regulation over IL-33 bioavailability and signaling intensity. Dysregulated IL-33–IL1RL1 signaling has been associated with excessive type 2 inflammation and a range of chronic allergic and inflammatory conditions, making IL1RL1 an important research target for investigating alarmin biology, mucosal immunity, and type 2 inflammatory mechanisms.
Fig. 1 Tissue injury triggers IL-33 secretion from epithelial/stromal cells; IL-33 signals through ST2 (IL1RL1) expressed on a broad spectrum of innate and adaptive immune cells to mediate type 2 inflammation, alloreactivity and tissue immune homeostasis.1
The biological functions of IL1RL1 are centered on IL-33 recognition, receptor complex assembly, type 2 inflammatory signaling, and regulation of tissue immune responses:
Creative Biolabs offers high-purity IL1RL1/ST2 proteins, including full-length ST2L, soluble sST2, and extracellular-domain constructs with defined glycosylation characteristics. These products support IL-33 binding studies, receptor interaction analysis, signaling research, and assay development. IL1RAP recruitment or downstream signaling activity is assessed only in appropriate trimeric-complex or cell-based assay formats. All proteins undergo purity and applicable functional testing to support reliable research use.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Creative Biolabs provides custom-engineered IL1RL1 stable cell lines, including overexpressing and knockdown models in mucosal epithelial and type 2 immune cell models. These cell lines are optimized for studying IL1RL1-mediated alarmin receptor heterodimer assembly mechanisms, IL-33 signal cascade dynamics, and anti-allergic compound sensitivity. Each cell line undergoes stringent validation, including stable expression detection and functional integrity verification.
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High-specificity recombinant antibodies targeting IL1RL1 are developed via advanced antibody engineering technologies. These antibodies are validated for multiple applications, including immunofluorescence for IL1RL1 mucosal membrane localization, Western blot for expression analysis, and co-immunoprecipitation for IL1RL1-receptor complex research, enabling precise analysis of IL1RL1 expression, subcellular localization and functional regulation.
Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!
Beyond catalog products, Creative Biolabs offers specialized custom services for IL1RL1 research:
IL1RL1 is an IL-33 alarmin co-receptor that forms heterodimeric complexes with IL1RAP to modulate type 2 inflammatory signal amplitude, balance mucosal barrier immune dynamics, and mediate allergic immune activation upon alarmin stimulation.
IL1RL1 is a core regulator of IL-33-driven type 2 innate immune signaling and mucosal immune homeostasis, and its dysregulation correlates with exaggerated allergic tissue inflammatory lesions. It acts as a pivotal research object for alarmin immunity and allergic disorder studies.
No, all IL1RL1 products and services are designed exclusively for research use and cannot be applied to clinical diagnosis or treatment.
Available products contain full-length and extracellular Ig domain IL1RL1 proteins, high-specificity recombinant antibodies, and custom stable mucosal cell lines to support alarmin and allergic inflammation research.
IL1RL1 proteins undergo IL-1 receptor heterodimer binding tests and alarmin signal functional verification to preserve native regulatory activity for immune research.
