Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
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The IL9 gene is located in the 5q31 region of human chromosome 5 and encodes interleukin 9 (IL-9), which belongs to the common cytokine receptor gamma-chain-dependent cytokine family. IL-9 is a secreted glycoprotein, synthesized as a precursor with a signal peptide and processed into a mature protein that adopts a four-α-helix bundle fold. Its molecular weight is approximately 14 kDa for the core protein, with extensive N-linked glycosylation increasing its apparent size to 20-30 kDa. IL-9 is produced primarily by CD4+ T cells, particularly Th9 cells, as well as Th2 cells, mast cells, eosinophils, and type 2 innate lymphoid cells. As a pleiotropic cytokine, IL-9 signals through a heterodimeric receptor composed of the IL-9 receptor alpha chain and the common gamma chain, activating JAK1/JAK3 and downstream STAT1, STAT3, and STAT5 signaling pathways. IL-9 acts as a growth factor for T cells, mast cells, and erythroid progenitors, and it enhances IgE production, mast cell proliferation, eosinophil development, and mucus production in allergic inflammation. The differentiation of Th9 cells is driven by IL-4 and TGF-β and requires the transcription factors IRF4 and PU.1. IL-9 is implicated in allergic diseases such as asthma, atopic dermatitis, and food allergy, as well as in certain lymphoid malignancies. Notably, IL-9-deficient mice are healthy with a largely normal immunophenotype, indicating that IL-9 is largely dispensable under basal conditions but functions as an amplifier in specific inflammatory contexts. Therefore, IL-9 is regarded as an important molecular target for studying Th9 cell biology, allergic inflammation, and cytokine signaling. Its functional analysis provides valuable tools for understanding the molecular basis of type 2 immune responses and allergic disease pathogenesis.
Fig. 1 IL-9 production and cellular sources.1
The functional spectrum of IL9 is extensive and is continuously expanding:
Creative Biolabs offers a series of high-quality IL9 recombinant protein products, suitable for structural and functional research. Relying on the independently developed MemDX™ recombinant protein technology platform, IL9 proteins can be prepared through various expression systems, including in vitro prokaryotic and eukaryotic expression systems. These rigorously validated protein products, such as recombinant human IL9 protein from various expression systems, can be used in ELISA, antibody screening and identification, receptor binding experiments, and functional research, providing reliable tools for researchers to analyze the signaling mechanisms and biological functions of IL9.
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Constructing a robust cell model is crucial for the study of IL9-mediated inflammatory signaling. As a pleiotropic cytokine that regulates allergic inflammation and immune cell function, the expression and secretion of IL9 directly influence downstream signaling output and cellular responses. Different genetic backgrounds, regulatory factors, or changes in expression levels may lead to significant differences in IL9 secretion and biological activity. Creative Biolabs offers customized IL9 stable transfection cell models, covering wild-type and various modified forms. These models stably express and secrete the target protein, and are suitable for studies on cytokine signaling, STAT pathway activation, receptor binding assessment, and functional evaluation of IL9 in immune and inflammatory responses, providing a reliable and reproducible platform for exploring the signaling mechanism, structure-function relationship, and regulatory network of IL9. Our technology ensures correct protein expression and secretion, facilitating your research.
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Creative Biolabs offers highly specific recombinant antibodies targeting IL9, produced using advanced recombinant antibody technology. Compared to traditional antibodies, these recombinant antibodies demonstrate superior performance in terms of specificity, sensitivity, and batch-to-batch consistency. They can also be modified and labeled in various ways. Our IL9 recombinant antibodies support a wide range of applications, including Western Blot, ELISA, flow cytometry, immunofluorescence, immunocytochemistry, immunohistochemistry, and immunoprecipitation, and can be used to detect differences in IL9 expression levels in various immune cell subsets or tissue sources, analyze its secretion profile, and conduct related research such as receptor-ligand interaction and cytokine signaling pathway analysis. These antibodies provide reliable detection tools for the structural analysis, functional study of IL9, and the analysis of its regulation in allergic and inflammatory signaling networks.
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In addition to the standard products, Creative Biolabs also offers professional customized services for IL9. IL9 is a secreted cytokine subject to extensive glycosylation and produced by multiple immune cell types with distinct regulatory mechanisms. These features present specific requirements in areas such as recombinant protein production, antigen design, and functional characterization. Leveraging our technology platform, we can assist you in completing the following customized projects:
IL-9 is a pleiotropic cytokine produced primarily by Th9 cells that promotes the proliferation and survival of T cells, mast cells, and erythroid progenitors, enhances IgE production, and drives allergic inflammation. It signals through the IL-9 receptor alpha chain and the common gamma chain to activate JAK1/JAK3 and downstream STAT pathways.
IL-9 is a key mediator of allergic inflammation and Th9 cell biology, implicated in asthma, atopic dermatitis, and food allergy, and it is dysregulated in certain lymphoid malignancies. Despite its largely dispensable role under basal conditions, IL-9 functions as an important amplifier in specific inflammatory contexts, making it valuable for studying cytokine signaling and type 2 immunity.
They are not. All IL9 products and services provided by Creative Biolabs are exclusively for research applications and may not be employed for any diagnostic, prophylactic, or therapeutic purpose in humans.
Multiple product formats are available, encompassing recombinant IL9 proteins, stable cell models expressing IL9, high-quality recombinant anti-IL9 antibodies, as well as comprehensive customized research services.
