Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
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Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
Polycystin 2, transient receptor potential cation channel (PKD2) is a multi-pass transmembrane channel protein encoded by the PKD2 gene, composed of six transmembrane helices, extracellular sensor loop and cytoplasmic regulatory C-terminal tail, and acts as a core pore-forming subunit for primary cilia cation channel complexes. PKD2 is widely expressed across polarized epithelial, renal tubular and ductal cell populations, serving as a core scaffold mediating channel heteromeric assembly and downstream ciliary calcium-dependent kinase recruitment upon luminal fluid stimulation.
PKD2 exerts its biological effects through heteromeric complex assembly with polycystin accessory subunits within primary ciliary membranes, a mechanism that modulates cilium calcium gradient stability and intracellular epithelial polarity signal cascade activation efficiency. Unlike auxiliary ciliary proteins, PKD2 cannot mediate sustained calcium sensing without complete heteromeric complex formation and relies on inter-subunit assembly to initiate full ciliary signal output; it recruits cytoplasmic signal mediators to assembled channel complexes, uncoupling extracellular fluid mechanical sensing from intracellular epithelial polarity transcription factor activation and sustaining persistent tissue homeostatic signals. This dual regulation modulates the intensity of cilia-triggered epithelial proliferative responses after fluid stimulation, fine-tuning local tubular cell growth and matrix mediator secretion levels, while sustained abnormal PKD2-mediated cation conduction drives unregulated epithelial proliferation and cystic tissue lesions. PKD2 participates in key physiological and pathological processes including primary cilia mechanosensing, epithelial polarity maintenance, fluid-mediated tissue expansion and chronic cystic proliferative disorders. Dysregulation of PKD2 expression or channel permeation capacity is closely associated with disrupted tubular tissue homeostasis and aberrant cyst formation, making PKD2 a crucial research target for ciliary TRP signaling, epithelial mechanotransduction and cystic disease research.
Fig. 1 Schematic of PC1/PC2 heterotetrameric TRPP cation channel with canonical S5-PH1-S6 TRP pore architecture; highlighted gain-of-function mutagenesis hotspots within PC1 and PC2 subunits that modulate cation permeation.1
The biological functions of PKD2 are focused on primary cilia TRP channel assembly, calcium mechanosignal propagation and tubular epithelial balance:
Creative Biolabs offers high-purity PKD2 proteins through optimized heterologous expression systems, including full-length PKD2 and isolated ciliary sensor domain variants with modified glycosylation status. These products retain native conformational characteristics and polycystin heteromeric binding activity, suitable for primary cilia mechanosensing research, membrane channel complex interaction detection, and small molecule anti-cystic compound screening for cystic disorder research. All PKD2 proteins undergo strict quality control, including purity analysis and biological activity validation to ensure biological function.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Creative Biolabs provides custom-engineered PKD2 stable cell lines, including overexpressing and knockdown models in renal tubular and ductal epithelial cell models. These cell lines are optimized for studying PKD2-mediated ciliary channel heteromer assembly mechanisms, ciliary calcium signal cascade dynamics, and anti-cystic compound sensitivity. Each cell line undergoes stringent validation, including stable expression detection and functional integrity verification.
Not finding the stable cell line product you need? Contact us to start your one-stop custom service!
High-specificity recombinant antibodies targeting PKD2 are developed via advanced antibody engineering technologies, with no cross-reactivity with other ciliary TRP channel subunits. These antibodies are validated for multiple applications, including immunofluorescence for PKD2 primary cilia membrane localization, Western blot for expression analysis, and co-immunoprecipitation for PKD2-polycystin complex research, enabling precise analysis of PKD2 expression, subcellular localization and functional regulation.
Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!
Beyond catalog products, Creative Biolabs offers specialized custom services for PKD2 research:
PKD2 is a primary ciliary polycystin TRP cation channel subunit that forms heteromeric complexes with polycystin partners to modulate fluid-induced ciliary calcium sensing amplitude, balance tubular epithelial proliferative dynamics, and mediate epithelial polarity maintenance under luminal mechanical stimulation.
PKD2 is a core regulator of ciliary calcium mechanotransduction and renal epithelial homeostasis, and its dysregulation is associated with unregulated ductal proliferation and chronic cystic tissue lesions. It is a critical target for ciliary TRP channel and polycystic disease research.
No, all PKD2 products and services are strictly for research use only, not intended for clinical diagnosis or treatment.
Offerings include PKD2 proteins (full-length, ciliary sensor domain variants), specific recombinant antibodies, and custom stable renal epithelial cell lines, supporting ciliary mechanosensing and cystic disorder research.
PKD2 proteins are validated by polycystin heteromeric complex binding assays and ciliary calcium signal regulation verification to ensure native regulatory function in primary cilia research.
