Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
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Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
Solute carrier family 25 member 1(SLC25A1, also known as CIC) is a mitochondrial inner membrane reverse transporter encoded by SLC25A1 gene, which is specifically located in the lipid bilayer of mitochondrial inner membrane and widely expressed in proliferating cells, epithelial cells and nerve cells. Different from other SLC25 family mitochondrial transporters, SLC25A1 mediates the reversible exchange process of citric acid and malic acid, which can transport citric acid in mitochondria to cytoplasm and transport cytoplasmic malic acid back to mitochondria. Under the steady state of metabolism, the moderate activity of SLC25A1 can provide citric acid substrate for cytoplasm to produce acetyl-CoA, and maintain the stability of physiological lipid synthesis and glycolysis flux. Under the condition of tumor proliferation or oxidative stress, the expression of SLC25A1 is up-regulated, which promotes the massive excretion of citric acid, accelerates the de novo synthesis of lipids, stabilizes FSP1 protein and enhances the viability of tumor cells. As a specific mitochondrial transporter with rate-limiting citric acid excretion function, its biological function can not be completely compensated by other transporters, and it can effectively connect mitochondrial tricarboxylic acid cycle with cytoplasmic anabolism and redox pathway. The loss of SLC25A1 function will exhaust the cytosolic acetyl coenzyme A reserve, inhibit tumor growth and enhance the sensitivity of cell iron death. The germ line mutation of this gene can induce compound 2- hydroxyglutaric aciduria, making it the core research target of mitochondrial vector biology and targeted screening of tumor metabolism.
SLC25A1 locates in the inner membrane of mitochondria and plays a reverse transport function. It relies on conservative substrate binding pocket to accurately mediate the two-way exchange of citric acid and malic acid, and its unique substrate selectivity makes it different from other tricarboxylic acid transport carriers. The protein-mediated metabolic shuttle system effectively connects mitochondrial energy metabolism with cytoplasmic lipid synthesis and redox regulation pathways, and can dynamically balance the level of synthetic metabolism and iron death resistance according to the cell proliferation state. SLC25A1 is widely involved in biological processes such as embryo metabolism regulation, neurolipid homeostasis maintenance and tumor metabolism reprogramming. The functional defect of SLC25A1 will lead to the depletion of cytoplasmic acetyl-CoA library and induce the abnormal accumulation of carcinogenic toxic metabolites. To sum up, SLC25A1 is the key research target of mitochondrial solute carrier mechanism research and metabolic targeted therapy screening.
Fig. 1 Schematic diagram of SLC25A1-ACLY-FSP1 axis regulating cellular ferroptosis via protein acetylation modification.1
The biological functions of SLC25A1 are focused on citrate-malate exchange, cytosolic acetyl-CoA production and ferroptosis regulation:
Creative Biolabs offers high-quality SLC25A1 proteins through optimized expression systems, including full mitochondrial carrier and isolated substrate-binding loop variants. These products retain native citrate-malate antiport biological activity, suitable for metabolite transport and metabolic modulator screening. All SLC25A1 proteins undergo strict quality control to ensure consistent performance and reliable application across diverse research platforms.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Creative Biolabs provides custom-engineered SLC25A1 stable cell lines, including overexpression and blank control models. These cell lines are optimized for mitochondrial carrier profiling and lipogenic/ferroptosis signal functional analysis. Each cell line undergoes stringent validation to ensure stable expression profiles and consistent functional performance in diverse experimental contexts.
Not finding the stable cell line product you need? Contact us to start your one-stop custom service!
High-specificity recombinant antibodies targeting SLC25A1 are developed via advanced antibody engineering technologies, with no cross-reactivity with other SLC25 mitochondrial carriers. These antibodies are validated for inner mitochondrial membrane localization detection and tumor/neural tissue profiling, and can be combined with metabolic enzyme markers to analyze citrate transport axis in cancer cell models.
Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!
Beyond catalog products, Creative Biolabs offers specialized custom services for SLC25A1 research:
SLC25A1 is mitochondrial citrate-malate antiporter that exports citrate to cytosol to supply acetyl-CoA for lipogenesis and regulate ferroptosis resistance.
SLC25A1 links mitochondrial TCA metabolism to tumor anabolic pathways and redox balance, a key target for metabolic cancer therapy.
No, all SLC25A1 products and services are strictly for research use only, not intended for clinical diagnosis or treatment.
Offerings include full SLC25A1 carrier proteins, isoform-specific detection antibodies and custom stable cell lines for metabolic research.
SLC25A1 proteins are validated via in vitro citrate-malate exchange transport assays.
