Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
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Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
TNF receptor superfamily member 14 (TNFRSF14), also known as HVEM, is a single-pass transmembrane immune receptor expressed on multiple immune and epithelial cell types. HVEM participates in a multi-ligand signaling network involving TNF superfamily ligands such as LIGHT/TNFSF14 and lymphotoxin-α, as well as immunoglobulin superfamily members BTLA and CD160. Depending on ligand identity, cis or trans interaction, and cellular context, HVEM signaling can promote either co-stimulatory or inhibitory immune responses. Through these context-dependent interactions, TNFRSF14 contributes to lymphocyte activation, immune homeostasis, and mucosal immune regulation, making it an important research target for immune receptor signaling and immunomodulation studies.
TNFRSF14 executes ligand-dependent immune regulatory function embedded in cell surface bilayers, utilizing conserved extracellular cysteine-rich ligand-binding domains to selectively engage matching TNF superfamily partners. Conserved binding pockets distinguish its ligand spectrum from other TNF receptors widely distributed across somatic cells. TNFRSF14-mediated signal transduction bridges extracellular ligand stimulation and intracellular lymphocyte survival transcription programs, balancing immune cell proliferation intensity based on local microbial load. TNFRSF14 participates in lymphoid organ development, mucosal immune cell residency and steady-state immune equilibrium maintenance. Deficient TNFRSF14 expression disrupts mucosal immune surveillance and impairs regional anti-infection capacity. Therefore, TNFRSF14 represents a pivotal research target for TNF superfamily receptor study and mucosal immune compound screening.
Fig. 1 Schematic diagram of TNFRSF14 (HVEM) multi-ligand interaction network: trans cellular binding with LIGHT, BTLA, CD160, decoy neutralization by DcR3, and cis HVEM-BTLA intramembrane inhibitory complex formation restricting LIGHT co-stimulation.1
The biological functions of TNFRSF14 are focused on superfamily ligand binding, intracellular signal adaptor recruitment and mucosal immune balance control:
Creative Biolabs offers high-quality TNFRSF14 proteins through optimized expression systems, including full-length transmembrane receptor and isolated extracellular ligand-binding domain variants. These products retain native ligand binding biological activity, suitable for receptor-ligand interaction assays and immune modulator screening. All TNFRSF14 proteins undergo strict quality control to ensure consistent performance and reliable application across diverse research platforms.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Creative Biolabs provides custom-engineered TNFRSF14 stable cell lines, including overexpression and blank control models. These cell lines are optimized for receptor expression profiling and lymphocyte survival signal functional analysis. Each cell line undergoes stringent validation to ensure stable expression profiles and consistent functional performance in diverse experimental contexts.
Not finding the stable cell line product you need? Contact us to start your one-stop custom service!
High-specificity recombinant antibodies targeting TNFRSF14 are developed via advanced antibody engineering technologies. These antibodies are validated for plasma membrane localization detection and lymphoid/mucosal tissue expression profiling, and can be combined with matching ligand detection reagents to analyze complete receptor-ligand immune complexes in primary immune cell models.
Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!
Beyond catalog products, Creative Biolabs offers specialized custom services for TNFRSF14 research:
TNFRSF14 is a transmembrane TNF superfamily receptor that binds corresponding ligands to sustain lymphocyte survival and maintain mucosal immune surveillance.
TNFRSF14 acts as a critical link between extracellular TNF ligand stimulation and mucosal immune cell homeostasis, governing regional anti-pathogen responses.
No, all TNFRSF14 products and services are strictly for research use only, not intended for clinical diagnosis or treatment.
Offerings include full-length TNFRSF14 membrane receptors, isoform-specific detection antibodies and custom stable cell lines for mucosal immune research.
TNFRSF14 proteins are validated via TNF superfamily ligand binding functional testing.
