Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights
Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
TNF receptor superfamily member 18 (TNFRSF18, GITR) is a transmembrane immune regulatory receptor encoded by TNFRSF18 gene, highly enriched on regulatory T cells and inducible on effector T lymphocytes, localized exclusively to plasma membrane lipid bilayers. Distinct from pro-apoptotic TNF receptor paralogs, TNFRSF18 engages its matching TNF superfamily ligand to recruit intracellular signaling mediators that modulate T cell suppressive capacity and limit overactive effector responses during sustained antigen exposure. Under steady immune conditions, low basal TNFRSF18 expression preserves baseline immune tolerance without full effector suppression. Upon persistent inflammatory stimulation, ligand-receptor crosslinking stabilizes regulatory T cell functional programs and restrains excessive pro-inflammatory cytokine release to promote tissue inflammatory resolution. Unlike broadly expressed TNF receptors with dual apoptotic roles, TNFRSF18 carries T cell-specific tolerogenic regulatory functions that cannot be fully substituted by other superfamily receptors, linking ligand recognition to peripheral immune tolerance pathways. Loss of functional TNFRSF18 weakens regulatory T cell suppressive activity and exacerbates autoimmune tissue inflammation, while sustained receptor ligation stabilizes immune tolerance states, establishing TNFRSF18 as a core research target for TNF receptor immunobiology and tolerance-inducing modulator screening.
TNFRSF18 executes tolerogenic immune receptor function embedded within T cell surface bilayers, utilizing conserved extracellular cysteine-rich domains to selectively bind its cognate TNF superfamily ligand. Conserved ligand-binding architecture separates its binding profile from apoptotic TNF receptors widely distributed across somatic cells. TNFRSF18-mediated signal transduction bridges extracellular ligand stimulation and intracellular regulatory T cell transcriptional programs, balancing effector immune response magnitude relative to persistent antigen load. TNFRSF18 participates in peripheral tolerance maintenance, autoimmune tissue inflammation control and memory T cell homeostasis. Deficient TNFRSF18 expression disrupts regulatory T cell suppressive signaling and impairs systemic inflammatory resolution capacity. Therefore, TNFRSF18 represents a pivotal research target for TNF superfamily tolerogenic receptor study and anti-autoimmune compound screening.
Fig. 1 Full schematic of TNFRSF18 (GITR): TNFR superfamily classification, extracellular CRD domain topology of GITR/GITRL, and comprehensive cellular functional network across Treg, effector T, DC, NK, macrophage and endothelial cells under GITRL stimulation.1
The biological functions of TNFRSF18 are focused on specific TNF ligand binding, regulatory signal transduction and peripheral tolerance control:
Creative Biolabs offers high-quality TNFRSF18/GITR proteins, including full-length receptors and isolated extracellular domains. Extracellular-domain constructs are suitable for GITRL binding, antibody, and structural studies, while receptor signaling should be evaluated using full-length GITR in cell-based models under defined TCR co-stimulation conditions. All proteins undergo appropriate quality control to support reliable research use.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Creative Biolabs provides custom-engineered TNFRSF18 stable cell lines, including overexpression and blank control models. These cell lines are optimized for tolerogenic receptor expression profiling and regulatory T cell signal functional analysis. Each cell line undergoes stringent validation to ensure stable expression profiles and consistent functional performance in diverse experimental contexts.
Not finding the stable cell line product you need? Contact us to start your one-stop custom service!
High-specificity recombinant antibodies targeting TNFRSF18 are developed via advanced antibody engineering technologies. These antibodies are validated for T cell plasma membrane localization detection and lymphoid tissue expression profiling, and can be combined with matching ligand detection reagents to analyze complete tolerogenic receptor-ligand complexes in primary T cell models.
Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!
Beyond catalog products, Creative Biolabs offers specialized custom services for TNFRSF18 research:
TNFRSF18 is a T cell-restricted TNF receptor that binds its cognate ligand to stabilize regulatory T cell suppressive function and limit chronic inflammation.
TNFRSF18 acts as a critical link between extracellular ligand stimulation and peripheral immune tolerance, restraining autoimmune inflammatory responses.
No, all TNFRSF18 products and services are strictly for research use only, not intended for clinical diagnosis or treatment.
Offerings include full-length TNFRSF18 membrane receptors, isoform-specific detection antibodies and custom stable cell lines for T cell tolerance research.
TNFRSF18 proteins are validated via cognate TNF superfamily ligand binding functional testing.
