Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
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Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
Translocase of outer mitochondrial membrane 20 (TOMM20) is a single-pass outer mitochondrial membrane receptor subunit encoded by the TOMM20 gene, serving as a primary precursor recognition component of the multi-subunit TOM translocase complex. TOMM20 contains an N-terminal transmembrane anchor with a short N-terminal segment facing the mitochondrial intermembrane space and a cytosolic C-terminal receptor domain that specifically binds positively charged mitochondrial targeting presequences of nuclear-encoded precursor proteins before guiding them into the central translocation pore formed by TOMM40. Without functional TOMM20, most mitochondrial precursor polypeptides fail to cross the outer membrane and accumulate in the cytosol to trigger cellular stress responses.
TOMM20 exerts precursor sorting function via positively charged binding grooves that electrostatically capture amphipathic mitochondrial presequences, then deliver captured substrates to the core TOM channel for intermembrane space translocation. Unlike other TOM subunits lacking ligand recognition domains, TOMM20 acts as the primary substrate filter determining import efficiency; suppressed TOMM20 expression blocks assembly of respiratory chain complexes, uncoupling mitochondrial biogenesis from cytoplasmic protein translation. This regulatory mechanism maintains steady organelle growth under physiological conditions, while TOMM20 downregulation is linked to multiple neurodegenerative syndromes with impaired mitochondrial function. TOMM20 participates in mitochondrial precursor import, organelle morphological maturation and neuronal degenerative lesions, making it a core marker for mitochondrial biogenesis research.
Fig. 1 TOMM20 (Tom20) serves as the primary receptor to recognize N-terminal mitochondrial presequences and deliver precursor proteins through TOM40 channel across outer mitochondrial membrane.1
The biological functions of TOMM20 are focused on mitochondrial targeting presequence capture and precursor channel delivery:
Creative Biolabs offers high-quality TOMM20 proteins through optimized heterologous expression systems, including full-length receptor and cytoplasmic presequence-binding domain variants with modified charged pocket characteristics. These products retain native targeting peptide affinity and TOM complex assembly capacity, suitable for mitochondrial import mechanistic assays and neuroprotective compound screening workflows. All TOMM20 batches undergo strict quality control to ensure consistent performance and reliable application across neuronal research platforms.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Creative Biolabs provides custom-engineered TOMM20 stable cell lines, including overexpressing and knockdown neuronal research models. These cell lines are optimized for mitochondrial import mechanism investigation and neuroprotective drug potency testing. Each cell line undergoes stringent validation to ensure stable outer membrane receptor expression profiles and consistent precursor import functional performance in diverse experimental contexts.
Not finding the stable cell line product you need? Contact us to start your one-stop custom service!
High-specificity recombinant antibodies targeting TOMM20 are developed via advanced antibody engineering technologies, with no cross-reactivity to other TOM complex subunits such as TOMM22/TOMM40. These antibodies are validated for multiple applications, including mitochondrial outer membrane immunofluorescence localization detection, Western blot expression quantification and co-immunoprecipitation analysis of full TOM translocase complexes, enabling precise characterization of TOMM20 expression levels and organelle membrane distribution under physiological and neurodegenerative conditions.
Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!
Beyond catalog products, Creative Biolabs offers specialized custom services for TOMM20 research:
TOMM20 is an outer mitochondrial translocase receptor that binds precursor targeting presequences, delivers polypeptides into TOM pores, and maintains steady mitochondrial biogenesis.
TOMM20 is the primary precursor recognition subunit of the TOM complex, and its loss disrupts organelle protein import and triggers neurodegeneration. It is a critical core research target for mitochondrial biology.
No, all TOMM20 products and services are strictly for research use only, not intended for clinical diagnosis or treatment.
Offerings include full-length TOMM20 receptor proteins, high-specificity recombinant antibodies, and custom mitochondrial import reporter cell lines, supporting neurodegenerative research projects.
TOMM20 proteins are validated by mitochondrial presequence peptide binding and precursor translocation assays to retain native organelle biogenesis regulatory function.
