Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
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Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
Translocator protein (TSPO), also known as peripheral benzodiazepine receptor (PBR), is an 18 kDa polytopic membrane protein located on the outer mitochondria membrane (OMM). This membrane protein can be found in most human tissues, especially abundantly expresses in the steroid-synthesising cells. TSPO is considered to be part of the mitochondrial permeability transition core complex, mainly located at inner-outer membrane contact sites. After being identified as a benzodiazepine target, the interest in TSPO as a pharmacological target has steadily increased. In mammals, it is believed that the major function of TSPO is to transfer cholesterol from OMM to the inner mitochondria membrane (IMM) with the cooperation of one or several other proteins. TSPO has been associated with a number of diseases, including various neurological disorders ( such as Alzheimer’s, Huntington’s, and Parkinson’s disease), anxiety disorders (such as generalised anxiety and posttraumatic stress disorder), and cancers (such as glioblastoma). Therefore, TSPO is considered as a promising pharmacological target, and its ligands also have been extensively studied as potential therapeutic or diagnostic tools.
Fig.1 TSPO localization and associated proteins.1
The functional repertoire of TSPO is extensive and continues to grow:
Company A offers an advanced selection of high-quality TSPO membrane protein products, essential for structural and functional studies. Our proprietary Magic™ Recombinant Membrane Protein technology enables the production of TSPO in various expression systems, including Virus-Like Particles (VLPs) and in vitro E. coli expression systems. These meticulously validated proteins, such as Magic™ Recombinant Mouse TSPO Membrane Protein in Virus-Like Particles (MP-VLPs) and human/mouse/pig TSPO expressed in HEK293 or E. coli systems, are designed for applications such as ELISA, antibody production and characterization, binding assays, and functional studies. They provide researchers with reliable tools for dissecting TSPO interactions and activity.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Developing robust cellular models is critical for TSPO research. Company A provides custom-engineered TSPO membrane protein stable cell lines that reliably express high levels of target TSPO. These stable cell lines are ideal for drug screening, ligand binding studies, functional assays, and high-throughput screening, offering a consistent and reproducible platform for investigating TSPO biology and pharmacology. Our expertise ensures optimal expression and cellular integrity, accelerating your research pipeline.
Not finding the stable cell line product you need? Contact us to start your one-stop custom service!
Our comprehensive portfolio includes high-affinity recombinant antibodies targeting TSPO, developed to meet the rigorous demands of various research applications. These antibodies, produced using advanced recombinant technologies, offer superior specificity, sensitivity, and batch-to-batch consistency compared to traditional polyclonal antibodies. Our TSPO recombinant antibodies are validated for use in Western Blotting (WB), ELISA, Flow Cytometry (FCM), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (IHC), and Immunoprecipitation (IP), empowering accurate detection and quantification of TSPO in diverse sample types.
Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!
Beyond our catalog products, Company A offers specialized custom services for membrane protein and antibody discovery & development. Leveraging our extensive expertise and state-of-the-art platforms, we can assist you with:
A1: TSPO is primarily involved in the transport of cholesterol into the mitochondria, a critical step for steroid hormone synthesis. It also plays roles in mitochondrial function, apoptosis, and cellular proliferation.
A2: TSPO's expression is significantly upregulated in various pathological conditions, including neuroinflammation, cancer, and stress-related disorders, making it a crucial biomarker and a promising therapeutic target.
A3: No, all Company A' TSPO products and services are strictly for research use only and are not intended for clinical diagnosis, prevention, treatment, or cure of any disease.
A4: We offer a range of products, including recombinant TSPO membrane proteins, stable cell lines expressing TSPO, and high-quality recombinant TSPO antibodies, along with comprehensive custom services.
