Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
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Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
Voltage dependent anion channel 1 (VDAC1) is the major pore-forming protein of the mitochondrial outer membrane, encoded by VDAC1 gene and belonging to the eukaryotic porin channel family, acting as the primary gateway for metabolite exchange between mitochondria and the cytosol. VDAC1 is ubiquitously expressed across somatic cell types, with evolutionarily conserved beta-barrel channel architecture and voltage-sensing gating motifs across species, serving as an essential modulator for ATP/ADP translocation, ion flux and mitochondrial apoptotic signal integration. VDAC1-mediated channel activity exerts decisive effects on sustaining intact mitochondrial bioenergetics, metabolite partitioning and cell death pathway control under physiological conditions. Furthermore, VDAC1 coordinates downstream signaling cascades governing mitochondrial permeability transition, apoptotic protein release and cellular energy balance to safeguard stable tissue function. Distinct from other VDAC paralogs with partially overlapping roles, VDAC1 carries unique non-redundant duties as the most abundant and widely expressed outer mitochondrial membrane channel, rendering it indispensable for normal metabolite transport, mitochondrial apoptosis regulation and overall cellular bioenergetic homeostasis.
VDAC1 executes biological functions through voltage-dependent gating of a large beta-barrel pore, enabling selective passage of nucleotides, metabolites and ions across the mitochondrial outer membrane while maintaining permeability barriers against larger proteins under resting conditions. Its conserved channel domains mediate pore formation, voltage sensing and interaction with cytosolic and mitochondrial binding partners, enabling precise tuning of metabolite flux and apoptotic signal transmission. VDAC1-dependent signaling sustains cellular bioenergetic equilibrium, covering controlled metabolite transport cycles, coordinated mitochondrial permeability regulation and persistent cell death surveillance. VDAC1 participates in an extensive spectrum of biological processes, such as nucleotide translocation, mitochondrial ion homeostasis, apoptotic protein release and cellular energy metabolism. Abnormal VDAC1 gating or interaction with regulatory partners disrupts mitochondrial metabolite balance, alters apoptotic threshold and elevates susceptibility to metabolic, neurodegenerative and malignant disorders. Therefore, VDAC1 constitutes a pivotal research target for investigating mitochondrial channel biology, cell death physiology and bioenergetic disease pathogenic mechanisms.
Fig. 1 Outer mitochondrial membrane VDAC1 acts as central channel mediating metabolite exchange and ER-mitochondrial Ca²⁺ signaling to regulate mitochondrial energy metabolism.1
The biological functions of VDAC1 are focused on beta-barrel channel formation, voltage-dependent gating and mitochondrial-cytosolic metabolite exchange:
Creative Biolabs offers high-quality VDAC1 proteins via optimized expression systems, covering full-length VDAC1 and isolated channel domain variants. These products retain native beta-barrel conformation and intrinsic voltage-dependent channel activity, suitable for channel-ligand interaction analysis, mitochondrial transport studies and VDAC1-targeted compound screening. All VDAC1 proteins undergo rigorous quality control to guarantee consistent functional performance and reliable application across diverse research platforms.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Creative Biolabs provides custom engineered VDAC1 stable cell lines, including overexpression and gene silencing models. These cell line models are optimized for mitochondrial channel research, apoptotic phenotype and bioenergetic compound response profiling. Each cell line undergoes strict validation procedures to ensure steady target expression levels and uniform functional performance across multiple experimental scenarios.
Not finding the stable cell line product you need? Contact us to start your one-stop custom service!
High-specificity recombinant antibodies targeting VDAC1 are developed with advanced antibody engineering workflows, without cross-reactivity against other VDAC family homologs. These antibodies receive multi-scenario functional validation, applicable to protein expression profiling, mitochondrial outer membrane localization detection, channel-protein binding assessment and mitochondrial research, enabling precise characterization of VDAC1 expression patterns, subcellular distribution and functional modulation under physiological and pathological states.
Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!
Beyond catalog products, Creative Biolabs offers specialized custom services for VDAC1 research:
VDAC1 is the major voltage-dependent anion channel of the mitochondrial outer membrane, forming a beta-barrel pore to mediate metabolite transport and regulate apoptotic signaling.
VDAC1 controls mitochondrial metabolite exchange and apoptotic threshold; dysregulated function contributes to metabolic, neurodegenerative and malignant pathologies, establishing it as a vital research target.
No, all VDAC1 products and services are strictly for research use only, not intended for clinical diagnosis or treatment.
Offerings include VDAC1 proteins, high-specificity recombinant antibodies and custom stable cell lines for mitochondrial channel biology and bioenergetic disorder research.
VDAC1 proteins undergo functional verification via channel activity assessment, voltage-dependent gating analysis and beta-barrel conformational stability evaluation.
