VIPR1 Membrane Protein Introduction

Introduction of VIPR1

VIPR1 is encoded by VIPR1 gene. It belongs to the G-protein-coupled receptor (GPCR) family which has been extensively studied during the past few decades because it offers numerous possibilities for therapeutic applications. VIPR1 is expressed in many tissues, such as the brain (cerebral cortex, hippocampus, amygdala), lung, prostate, peripheral blood leukocytes, liver, small intestine, heart, spleen, placenta, kidney, thymus, and testis. Meanwhile, studies show that VIPR1 is related to natural virus-related peptides and the pharmacological effects of synthetic agonists or antagonists.

Basic Information of VIPR1
Protein Name	Vasoactive intestinal polypeptide receptor 1
Gene Name	VIPR1
Aliases	VPAC1
Organism	Homo sapiens (Human)
UniProt ID	P32241
Transmembrane Times	7
Length (aa)	457
Sequence	MRPPSPLPARWLCVLAGALAWALGPAGGQAARLQEECDYVQMIEVQHKQCLEEAQLENETIGCSKMWDNLTCWPATPRGQVVVLACPLIFKLFSSIQGRNVSRSCTDEGWTHLEPGPYPIACGLDDKAASLDEQQTMFYGSVKTGYTIGYGLSLATLLVATAILSLFRKLHCTRNYIHMHLFISFILRAAAVFIKDLALFDSGESDQCSEGSVGCKAAMVFFQYCVMANFFWLLVEGLYLYTLLAVSFFSERKYFWGYILIGWGVPSTFTMVWTIARIHFEDYGCWDTINSSLWWIIKGPILTSILVNFILFICIIRILLQKLRPPDIRKSDSSPYSRLARSTLLLIPLFGVHYIMFAFFPDNFKPEVKMVFELVVGSFQGFVVAILYCFLNGEVQAELRRKWRRWHLQGVLGWNPKYRHPSGGSNGATCSTQVSMLTRVSPGARRSSSFQAEVSLV

Function of VIPR1 Membrane Protein

The VPAC1 protein-coupled receptor can mediate the activity of immunomodulatory (primarily anti-inflammatory) actions of peptides, such as vasoactive intestinal peptide (VIP) and pituitary adenylyl cyclase-activating polypeptide (PACAP). Many studies conducted on VPAC1 show it is associated with various diseases, like, cancer, Postmenopausal osteoporosis, and Huntington's Disease. Patients with idiopathic achalasia show a significant difference in the distribution of SNPs affecting VIPR1, which suggests it could be a potential therapeutic target in the clinic.

Fig.1 Structure of VIPR1 membrane protein.

Application of VIPR1 Membrane Protein in Literature

Lindner S., et al. Design, synthesis and in vitro evaluation of heterobivalent peptidic radioligands targeting both GRP- and VPAC1-Receptors concomitantly overexpressed on various malignancies - Is the concept feasible? Eur J Med Chem. 2018, 155: 84-95. PubMed ID: 29864700

This article describes a radiolabeled heterobivalent peptidic ligands (HBPLs), comprising a GRPR-binding (BBN7-14) and a VPAC1R-targeting (PACAP-27) peptide, to provide new ideas for tumor imaging and therapy.
Peyrassol X., et al. Development by genetic immunization of monovalent antibodies against human vasoactive intestinal peptide receptor 1 (VPAC1), new innovative, and versatile tools to study VPAC1 receptor function. Front Endocrinol (Lausanne). 2018, 9: 153. PubMed ID: 29674997

This article selects nine monovalent antibodies (sdAbs) targeting the vasoactive intestinal peptide receptor 1 (VPAC1) receptor and studies the effect of VPAC1 antagonist. These results provide evidence on further investigate the role of VPAC1 in physiological and pathological conditions.
Musumeci G., et al. Identification of dysregulated microRNA networks in Schwann cell-like cultures exposed to immune challenge: potential crosstalk with the protective VIP/PACAP neuropeptide system. Int J Mol Sci. 2018, 19(4). PubMed ID: 29587404

Authors in this group analyze the expression of selected miRNAs in the rat RT4 Schwann lipopolysaccharide (LPS) cell line by real-time qPCR, Western blot and ELISAs. Results show that the expression levels of pro-inflammatory cytokines, VIP and PACAP are increased.
Abad C., et al. VPAC1 receptor (Vipr1)-deficient mice exhibit ameliorated experimental autoimmune encephalomyelitis, with specific deficits in the effector stage. J Neuroinflammation. 2016, 13(1): 169. PubMed ID: 27357191

This article focuses on investigating the involvement of VPAC1 in the development of experimental autoimmune encephalomyelitis (EAE) using a VPAC1-deficient mouse model.
Tavaglione F., et al. The SNP rs9677 of VPAC1 gene is associated with glycolipid control and heart function in female patients with type 2 diabetes: A follow-up study. Nutr Metab Cardiovasc Dis. 2016, 26(2): 109-13. PubMed ID: 26712708

This article evaluates the single-nucleotide polymorphism (SNP) rs9677, mapped in vasoactive intestinal peptide receptor 1 (VPAC1), and trying to confirm the association between rs9677 and type 2 diabetes (T2D) in female patients.

VIPR1 Preparation Options

To obtain the soluble and functional target protein, the versatile Magic™ membrane protein production platform in Creative Biolabs enables many flexible options, from which you can always find a better match for your particular project. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-VIPR1 antibody development services.

As a forward-looking research institute as well as a leading custom service provider in the field of membrane protein, Creative Biolabs has won good reputation among our worldwide customers for successfully accomplishing numerous challenging projects including generation of many functional membrane proteins. Please feel free to contact us for more information.

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