Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
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Conventional bacterial display lacks eukaryotic post-translational modification machinery, hindering proper folding of complex or constrained peptides and resulting in false positives and poor in vivo translatability. Our yeast display platform leverages eukaryotic secretion, chaperones and native PTM pathways to identify therapeutically relevant functional peptides, yielding low nM-to-pM high-affinity binders and epitope-specific peptides compatible with cyclic/stapled formats, while enabling screening against intractable targets including GPCRs and ion channels. Powered by AI-augmented ultra-large libraries, we deliver validated peptide leads from target antigens, with comprehensive binding data, sequence IDs and off-target profiling to boost hit rates and minimize downstream attrition. |
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Creative Biolabs provides a mature and robust yeast display system, dedicated to accelerating the discovery and development of target proteins and antibodies. We offer a full spectrum of customized services to fully support your entire project workflow for binder discovery based on yeast display technology.
Yeast Display based MHC-Peptide Discovery
Construct high-diversity peptide libraries via yeast display technology to simulate the antigen processing process, and screen neoantigens or epitopes with high affinity binding to specific MHC molecules (HLA-A, B, C, etc.).
Yeast Display based Evolutionary Optimization of Peptide
For existing lead peptides, secondary libraries are constructed via error-prone PCR or saturation mutagenesis. Mutants with stronger binding affinity (pM-level KD) or superior stability are strictly screened by FACS.
Yeast Display based Ligand-Receptor Interaction
We offer ligand identification for receptors and comprehensive ligand library screening against specific receptors, to elucidate key interaction sites in signal transduction pathways.
Yeast Display based PTM Analysis in Peptide
Endogenous yeast modification enzymes or exogenously engineered enzymes such as kinases and glycosyltransferases are utilized to display peptides bearing phosphorylation, glycosylation and other post-translational modifications, for the screening of PTM-dependent specific antibodies and binding proteins.
Yeast Display based AI-Driven Peptide Library Design & Screening
Integrate machine-learning algorithms such as deep learning and generative models with yeast display technology. Primary data obtained from the first round of screening is used to train models for predicting and optimizing secondary libraries with higher affinity.
Our Yeast Display Platform leverages the eukaryotic secretory pathway, enabling proper folding and post-translational modifications of complex peptides. The covalent linkage between genotype and phenotype allows direct flow cytometry screening with quantitative affinity resolution. Key capabilities include: multi-parameter sorting, magnetic enrichment for rare clones, and compatibility with both linear and constrained peptide libraries. Yeast's large surface enables robust expression of difficult peptides (hydrophobic, cyclic, phosphorylated).
Yeast's eukaryotic machinery ensures proper phosphorylation, glycosylation, and proline isomerization – crucial for functional peptide therapeutics.
Multi-parametric sorting at >108 events; we routinely recover rare clones with sub-nanomolar affinity.
Engineered strains reduce background and increase transformation efficiency. Our semi-synthetic peptide libraries cover loop, linear, and constrained architectures.
A proven history of successfully executed peptide discovery projects. Our robust platform ensures high library diversity and predictable, efficient lead identification aligned with your research timelines.
Explore our complete suite of yeast display technology offerings:
Custom library design and construction covering diverse peptide scaffolds and diversities.
High-throughput FACS-based screening against soluble, membrane-bound, or complex antigen targets.
Rationally improve antibody lead affinity and biophysical properties.
Enhance TCR specificity, affinity, or stability for cell therapy applications.
Full human antibody discovery from naïve or immune yeast display libraries.
End-to-end antibody hit generation against challenging targets.
Improve expression, stability, or activity of protein leads through directed evolution.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
