Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | C5a anaphylatoxin chemotactic receptor 2 |
| Gene Name | C5AR2 |
| Uniprot | Q9P296 (Human); Q8BW93 (Mouse) |
| Synonym | C5L2; GPF77; GPR77; C5a anaphylatoxin chemotactic receptor 2; C5a anaphylatoxin chemotactic receptor C5L2; G protein-coupled receptor 77 |
| Background | C5AR2 is one of the receptors of C5a, which is a potent peptide chemoattractant and an effective inflammatory mediator. It was discovered in 2000 and, despite its relatively short history, its function has been the subject of controversy. The receptor falls within the larger 7-transmembrane G-protein coupled receptor family and binding with C5a occurs with contribution from all extracellular domains of the receptor. On the intracellular domains, C5AR2 lacks the conserved residues necessary for G-protein coupling. As a result, C5AR2 is generally described as a modulator of C5AR1 signaling, exerting either anti- or pro-inflammatory activities. On one hand, C5AR2 may mediate anti-inflammatory effects by controlling the availability of C5a for the other receptor, C5AR1. On the other hand, it may induce G protein-independent activation of immune cells, thus exerting pro-inflammatory effects. |
Creative Biolabs offers a comprehensive range of membrane protein products that empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-0423-KX353 | MemDX™ Membrane Protein Human C5AR2 (1-38aa) Expressed in HEK293, C-Human Fc tag | HEK293 cells | Partial | N/A |
| Please contact us for more products or customization | ||||
J***an:: I recently purchased a protein from Creative Biolabs, and I must say I am thoroughly impressed! The purity of the protein is exceptional, and it has maintained its activity very well. It performed outstandingly in our experiments and met all our research requirements. Additionally, their customer service is top-notch.
21/Sep/2024
With our innovative approaches and comprehensive services, Creative Biolabs is dedicated to advancing C5AR2 gene therapy. We provide tailored solutions to meet your specific requirements. Please for more services.
Creative Biolabs offers viral vector-mediated gene delivery services. AAV vectors are highly efficient for gene delivery to various tissues, including neurons and muscle cells. AAV vectors can be engineered to specifically target C5AR2 expression in tissues affected by diseases related to C5AR2 dysfunction.
Creative Biolabs offers non-viral gene delivery services. LNPs can encapsulate DNA or mRNA encoding the C5AR2 gene and deliver it to target cells. Depending on the lipid composition and targeting ligands, LNPs can also deliver C5AR2 gene constructs to tissues.
Creative Biolabs offers gene knockout and replacement services. Gene editing can knock out a defective C5AR2 gene and replace it with a healthy copy. This approach can restore normal C5AR2 function in affected cells.
Creative Biolabs provides advanced services integral to progressing the development pipeline for C5AR2-directed cell therapies. Our methodologies ensure robust, high-fidelity outcomes; further details regarding specific service capabilities are available upon request. Please for more services.
Creative Biolabs offers transgenic and knockout mouse models. To rigorously investigate the C5AR2 receptor's contribution to immune cell function in vivo, transgenic and C5AR2-knockout murine models are employed. These sophisticated biological systems represent indispensable platforms. They are critical not only for dissecting the receptor's physiological activities and its complex involvement in pathological states but also for fundamentally informing the rational design of targeted therapeutic interventions.
Creative Biolabs provides RNA sequencing and transcriptomic analysis services. Thorough transcriptomic examination is accomplished through bulk RNA sequencing performed on C5AR2 knockout cells. This robust analytical method enables the accurate detection of genes with differential regulation and their related molecular pathways. As a result, it clarifies the subsequent consequences of C5AR2 regulation, while also spotlighting potential weak points or targets suitable for therapeutic intervention.
Creative Biolabs offers cytokine and chemokine analysis services. Quantitative assessment of cytokine and chemokine expression profiles following targeted C5AR2 modulation serves a crucial dual purpose. It delineates the specific immunomodulatory consequences mediated by the receptor. This analysis concurrently facilitates the identification of putative biomarkers essential for monitoring therapeutic efficacy and patient response stratification.
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All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
