Introduction of CACNG5
Encoded by CACNG5 gene, CACNG5 belongs to the neuronal calcium channel gamma subunit subfamily which has been extensively studied during the past few decades because it offers numerous possibilities for therapeutic applications. It is one of the five subunits of L-type calcium channels. Recent studies show it is associated with bipolar disorder and schizophrenia.
|Basic Information of CACNG5|
|Protein Name||Voltage-dependent calcium channel gamma-5 subunit|
|Organism||Homo sapiens (Human)|
Function of CACNG5 Membrane Protein
Mapping to chromosome 17q24, CACNG5 gene encodes an integral membrane protein that was originally isolated as the regulatory gamma subunit of voltage-dependent Ca2+ channels. As a type II transmembrane AMPA receptor regulatory protein (TARP), CACNG5 can regulate the gating properties of AMPA-selective glutamate receptors (AMPARs) by accelerating their rates of activation, deactivation, and desensitization. It is commonly expressed in lots of tissues, such as the brain, lymph node, as well as spleen. Recent studies show that it may contribute to the risk of schizophrenia. It is documented that the lncRNA LINC00880 targeting CACNG5 can inhibit cell apoptosis and promote proliferation, migration, and invasion in spinal cord ependymoma (SCE) through the MAPK signaling pathway.
Fig.1 Structure of p38 MAPK Pathway.
Application of CACNG5 Membrane Protein in Literature
This article analyses the positive expression of the CACNG5 protein, LINC00880, and MAPK signaling pathway-related proteins in spinal cord ependymoma (SCE) tissues. These results demonstrate that lncRNA LINC00880 targeting CACNG5 inhibits cell apoptosis and promotes proliferation, migration, and invasion in SCE through the MAPK signaling pathway.
Authors conduct a large-scale association study in Han Chinese individuals. The data suggest the SNP rs17645023 located in the intergenic region of CACNG4 and CACNG5 is identified to be significantly associated with schizophrenia.
Authors in this group conduct genome-wide association studies and compare marker allele frequencies between the samples of UK bipolar and schizophrenic. These results indicate that CACNG5 plays a key role in voltage-dependent calcium channel genes in the susceptibility to bipolar disorder and/or schizophrenia.
CACNG5 Preparation Options
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