Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsThe ferret is a common laboratory animal. It plays an important role in the study of viral infectious diseases such as flukes, canine distemper virus, and others. In addition, it provides unique experimental models for diseases such as measles, herpes stomatitis, aleutian disease, cerebellar hypoplasia, and bovine rhinotracheitis. In conclusion, the ferret's contribution to human health is undoubtedly important. And the development of monoclonal ferret antibodies is a potential opportunity for the discovery of novel target binding agents with high specificity and affinity. Based on our rich field experience and advanced antibody preparation platform, Creative Biolabs provides comprehensive antibody discovery services to support monoclonal ferret antibody production.
Ferrets are carnivores and belong to the family Mustelidae. Domesticated for experimental purposes, ferrets have wild-colored or albino fur, yellowish body hair, black faces, feet, and tails. Since 1911, when the first report of biomedical research using domesticated ferrets was published, ferrets have played an important role as experimental animals in biochemistry, pharmaceutical research, and other fields. Ferrets have been invaluable models in cardiac research, spinal cord injuries, epilepsy, and a variety of lung diseases.
Ferrets have several advantages in the study of influenza viruses. The physiologic structure and anatomy of the ferret's respiratory tract are closer to those of humans than to those of mice. The clinical signs of its infection with the influenza virus are also very similar to those of human influenza, including coughing, runny nose, sneezing, and fever. In addition, the ferret's lungs are similar to those of humans. Therefore, ferrets are ideally suited for studies of influenza pathogenesis, transmission, and vaccine efficacy. In addition, the cortical structure of the ferret brain gives it a natural advantage in brain research. Ferrets have a larger neocortex and more basal radial glial cells than mice. The complexity of the cortex and their ability to reproduce rapidly and freely make them important model animals for brain research. Ferrets have contributed greatly to our understanding of the brain and its functions. In addition, ferrets are diphyodont animals and share similar dental patterns with humans. Therefore, it can be used for dental research and dental diseases.
However, the relatively high cost and the lack of reagents suitable for ferrets limit the ferret model's research application. The discovery of phage display technology brings new hope for the preparation of ferret antibodies. The rapid preparation of ferret antibodies can be realized by phage display library construction. Common phage display libraries are natural libraries, immune antibody libraries, and synthetic libraries. Natural antibody libraries are antibody libraries constructed using lymphocytes that are not immunized. They usually have the advantages of large library capacity and good diversity. However, most of the antibody sequences in natural antibody libraries are from IgM, which is not stimulated and matured, and therefore the in vivo affinity is weaker than that of the IgG type. The immune antibody library is constructed from the antibody genes of donor B lymphocytes after immunization. Due to the selective pressure of immunization, the abundance of specific antibodies against the corresponding immunogens in the immune antibody pool is much higher than that of other non-specific antibodies. Some of these specific antibodies have undergone the affinity maturation process of the immune system, and thus high affinity and high specificity antibodies can be screened from this immune antibody library.
Creative Biolabs has a wealth of knowledge and experience in monoclonal antibody discovery. We would be happy to share with you our knowledge and experience related to monoclonal ferret antibody discovery.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
