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NativeExtract™ Human CCR3 Membrane Protein (Full length, Super Nanodisc) (CAT#: S01YF-1023-KX462)

Datasheet
This product is recombinant Human CCR3 protein in native nanodisc form. The synthetic compound we developed can solubilize the CCR3 protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • CCR3
  • Protein Length
  • Full length
  • Molecular Weight
  • 41.0 kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • Flag tag at the C-terminus
  • Protein Format
  • Native Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • CCR3
  • Full Name
  • C-C motif chemokine receptor 3
  • Introduction
  • The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants have been described.
  • Alternative Names
  • CKR3; CD193; CKR 3; CMKBR3; C C CKR3; CC-CKR-3; C-C chemokine receptor type 3; C-C CKR-3; CC chemokine receptor 3; CCR-3; b-chemokine receptor; chemokine (C-C motif) receptor 3; eosinophil CC chemokine receptor 3; eosinophil eotaxin receptor; CCR3; C-C motif chemokine receptor 3

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