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NPY2R Membrane Protein Introduction

Introduction of NPY2R

Neuropeptide Y receptor 2 (NPY2R) is a protein that in humans is encoded by the NPY2R gene, and is a member of the Neuropeptide Y receptor family. It also belongs to the G-protein-coupled receptor superfamily. NPY receptor family comprises four functional NPY receptor subtypes (Y1R, Y2R, Y4R Y5R), it exerts a variety of physiological processes in humans via four different receptor subtypes, which are widely distributed in the central and peripheral nervous system and involved in the regulation of numerous physiological functions.

Basic Information of NPY2R
Protein Name Neuropeptide Y receptor type 2
Gene Name NPY2R
Aliases NPY-Y2 receptor, Y2 receptor
Organism Homo sapiens (Human)
UniProt ID P49146
Transmembrane Times 7
Length (aa) 381
Sequence MGPIGAEADENQTVEEMKVEQYGPQTTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSIILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKRISFLIIGLAWGISALLASPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYTRIWSKLKNHVSPGAANDHYHQRRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSVTFKAKKNLEVRKNSGPNDSFTEATNV

Function of NPY2R Membrane Protein

The neuropeptide Y system is one of the best-known modulators of the stress response, and some of its effects are mediated through the NPY2R. NPY2R is the most abundant Y subtype receptor in the central nervous system and implicated with food intake, bone formation, affective disorders, alcohol and drugs of abuse, epilepsy, pain, and cancer. Furthermore, NPY2R affect iconic memory processes using a partial report paradigm, and it plays an important role in therapeutics development.

NPY2R Membrane Protein Introduction

Application of NPY2R Membrane Protein in Literature

  1. Treutlein J., et al. Association between neuropeptide Y receptor Y2 promoter variant rs6857715 and major depressive disorder. Psychiatric genetics. 2017, 27(1): 34-7. PubMed ID: 27584037.

    This article showed the neuropeptide Y system is one of the best-known modulators of the stress response, and some of its effects are mediated through the NPY2R. The functional NPY2R variant rs6857715 (C-599T) has been implicated in both obesity and alcohol dependence, but with opposing alleles.

  2. Beste C., et al. On the relevance of the NPY2-receptor variation for modes of action cascading processes. NeuroImage. 2014, 102 Pt 2: 558-64. PubMed ID: 25157429.

    This article aimed at determining the possible relevance of the NPY2 receptor for action cascading processes and this study investigates a functional promoter variation (rs2234759) in the NPY2R. The behavioral data show that the NPY2R high expression G allele is associated with a less efficient mode of action cascading where different task goals are activated in parallel.

  3. Arning L., et al. NPY2-receptor variation modulates iconic memory processes. European neuropsychopharmacology. 2014, 24(8): 1298-302. PubMed ID: 24709141.

    This article found that iconic memory decayed much faster in individuals carrying the rare promoter NPY2R G allele which is associated with increased expression of the Y2 receptor. And the results provided evidence that the functionally relevant single nucleotide polymorphism (SNP) in the NPY2R promoter gene affect circumscribed processes of early sensory processing.

  4. Schmidt P., et al. The G-protein-coupled neuropeptide Y receptor type 2 is highly dynamic in lipid membranes as revealed by solid-state NMR spectroscopy. Chemistry. 2014, 20(17): 4986-92. PubMed ID: 24623336.

    This article showed the NPY2R is highly dynamic in lipid membranes as revealed by solid-state NMR spectroscopy. And they found the molecular mobility of the human NPY2R reconstituted into dimyristoylphosphatidylcholine (DMPC) membranes was investigated by means of solid-state NMR spectroscopy.

  5. Mittapalli G.K., et al. Ligands of the neuropeptide Y Y2 receptor. Bioorganic & medicinal chemistry letters. 2014, 24(2): 430-41. PubMed ID: 24365162.

    This article showed the lack of small molecule non-peptidic Y2 receptor modulators suitable as in vivo pharmacological tools hampered the progress to uncover the precise pharmacological role of Y2.

NPY2R Preparation Options

To obtain the soluble and functional target protein, the versatile Magic™ membrane protein production platform in Creative Biolabs enables many flexible options, from which you can always find a better match for your particular project. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-NPY2R antibody development services.


As a forward-looking research institute as well as a leading customer service provider in the field of membrane protein, Creative Biolabs has won good reputation among our worldwide customers for successfully accomplishing numerous challenging projects including generation of many functional membrane proteins. Please feel free to contact us for more information.

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