Introduction of NPY2R
Neuropeptide Y receptor 2 (NPY2R) is a protein that in humans is encoded by the NPY2R gene, and is a member of the Neuropeptide Y receptor family. It also belongs to the G-protein-coupled receptor superfamily. NPY receptor family comprises four functional NPY receptor subtypes (Y1R, Y2R, Y4R Y5R), it exerts a variety of physiological processes in humans via four different receptor subtypes, which are widely distributed in the central and peripheral nervous system and involved in the regulation of numerous physiological functions.
|Basic Information of NPY2R|
|Protein Name||Neuropeptide Y receptor type 2|
|Aliases||NPY-Y2 receptor, Y2 receptor|
|Organism||Homo sapiens (Human)|
Function of NPY2R Membrane Protein
The neuropeptide Y system is one of the best-known modulators of the stress response, and some of its effects are mediated through the NPY2R. NPY2R is the most abundant Y subtype receptor in the central nervous system and implicated with food intake, bone formation, affective disorders, alcohol and drugs of abuse, epilepsy, pain, and cancer. Furthermore, NPY2R affect iconic memory processes using a partial report paradigm, and it plays an important role in therapeutics development.
Application of NPY2R Membrane Protein in Literature
This article showed the neuropeptide Y system is one of the best-known modulators of the stress response, and some of its effects are mediated through the NPY2R. The functional NPY2R variant rs6857715 (C-599T) has been implicated in both obesity and alcohol dependence, but with opposing alleles.
This article aimed at determining the possible relevance of the NPY2 receptor for action cascading processes and this study investigates a functional promoter variation (rs2234759) in the NPY2R. The behavioral data show that the NPY2R high expression G allele is associated with a less efficient mode of action cascading where different task goals are activated in parallel.
This article found that iconic memory decayed much faster in individuals carrying the rare promoter NPY2R G allele which is associated with increased expression of the Y2 receptor. And the results provided evidence that the functionally relevant single nucleotide polymorphism (SNP) in the NPY2R promoter gene affect circumscribed processes of early sensory processing.
This article showed the NPY2R is highly dynamic in lipid membranes as revealed by solid-state NMR spectroscopy. And they found the molecular mobility of the human NPY2R reconstituted into dimyristoylphosphatidylcholine (DMPC) membranes was investigated by means of solid-state NMR spectroscopy.
This article showed the lack of small molecule non-peptidic Y2 receptor modulators suitable as in vivo pharmacological tools hampered the progress to uncover the precise pharmacological role of Y2.
NPY2R Preparation Options
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