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NativeExtract™ Recombinant Full Length Human ACHA2 Protein (Nanodisc, FLAG- & Strep-tagged) (CAT#: SYF-0426-CW253)

Datasheet
This product is recombinant Human ACHA2 protein in native nanodisc form. The synthetic compound we developed can solubilize the ACHA2 protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • ACHA2
  • Protein Length
  • Full length
  • Protein Class
  • Ion Channel
  • Molecular Weight
  • 59.8 kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • The recombinant protein is constructed with FLAG Tag & Strep Tag at C-terminus.
  • Protein Format
  • Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • ACHA2
  • Full Name
  • Cholinergic Receptor Nicotinic Alpha 2 Subunit
  • Introduction
  • Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels formed by a pentameric arrangement of alpha and beta subunits to create distinct muscle and neuronal receptors. Neuronal receptors are found throughout the peripheral and central nervous system where they are involved in fast synaptic transmission. This gene encodes an alpha subunit that is widely expressed in the brain. The proposed structure for nAChR subunits is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. Mutations in this gene cause autosomal dominant nocturnal frontal lobe epilepsy type 4. Single nucleotide polymorphisms (SNPs) in this gene have been associated with nicotine dependence.
  • Alternative Names
  • Cholinergic Receptor Nicotinic Alpha 2 Subunit; Cholinergic Receptor, Nicotinic, Alpha Polypeptide 2 (Neuronal); Acetylcholine Receptor, Nicotinic, Alpha 2 (Neuronal); Cholinergic Receptor, Nicotinic, Alpha 2 (Neuronal); Cholinergic Receptor, Nicotinic Alpha 2

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