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NativeExtract™ Recombinant Full Length Human HCN4 Protein (Nanodisc, FLAG- & Strep-tagged) (CAT#: SYF-0426-CW41)

This product is recombinant Human HCN4 protein in native nanodisc form. The synthetic compound we developed can solubilize the HCN4 protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • HCN4
  • Protein Length
  • Full length
  • Protein Class
  • Immune Checkpoint Inhibitor
  • Molecular Weight
  • 129 kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • The recombinant protein is constructed with FLAG Tag & Strep Tag at C-terminus.
  • Protein Format
  • Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • HCN4
  • Full Name
  • Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4
  • Introduction
  • This gene encodes a member of the hyperpolarization-activated cyclic nucleotide-gated potassium channels. The encoded protein shows slow kinetics of activation and inactivation, and is necessary for the cardiac pacemaking process. This channel may also mediate responses to sour stimuli. Mutations in this gene have been linked to sick sinus syndrome 2, also known as atrial fibrillation with bradyarrhythmia or familial sinus bradycardia. Two pseudogenes have been identified on chromosome 15.
  • Alternative Names
  • Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4; Potassium/Sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 4; Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 4; Hyperpolarization Activated Cyclic Nucleotide-Gated Cation Channel 4; SSS2

Case Studies

Customer reviews and Q&As    

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