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NativeExtract™ Recombinant Full Length Human ACHB4 Protein (Nanodisc, FLAG- & Strep-tagged) (CAT#: SYF-0426-CW268)

This product is recombinant Human ACHB4 protein in native nanodisc form. The synthetic compound we developed can solubilize the ACHB4 protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • ACHB4
  • Protein Length
  • Full length
  • Protein Class
  • Ion Channel
  • Molecular Weight
  • 56.4 kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • The recombinant protein is constructed with FLAG Tag & Strep Tag at C-terminus.
  • Protein Format
  • Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • ACHB4
  • Full Name
  • Cholinergic Receptor Nicotinic Beta 4 Subunit
  • Introduction
  • This gene is found within a conserved gene cluster and encodes one of the beta subunits of the nicotinic acetylcholine receptor (nAChRs) superfamily which form ligand-gated ion channels with a central pore that forms a cation channel. Neuronal nAChRs are pentameric structures that can be either homomeric or heteromeric, with heteromeric structures containing both alpha and beta subunits. Each subunit contains an extracellular amino terminus and four transmembrane domains. Nicotine is one of the agonists that binds to the receptor. Variants in this gene have been associated with nicotine dependence and lung cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.
  • Alternative Names
  • Cholinergic Receptor Nicotinic Beta 4 Subunit; Acetylcholine Receptor, Nicotinic, Beta 4 (Neuronal); Cholinergic Receptor, Nicotinic, Beta Polypeptide 4; Cholinergic Receptor, Nicotinic, Beta 4 (Neuronal); Cholinergic Receptor, Nicotinic Beta 4

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