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NativeExtract™ Recombinant Full Length Human KCD11 Protein (Nanodisc, FLAG- & Strep-tagged) (CAT#: SYF-0426-CW173)

Datasheet
This product is recombinant Human KCD11 protein in native nanodisc form. The synthetic compound we developed can solubilize the KCD11 protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • KCD11
  • Protein Length
  • Full length
  • Protein Class
  • Ion Channel
  • Molecular Weight
  • 25.9 kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • The recombinant protein is constructed with FLAG Tag & Strep Tag at C-terminus.
  • Protein Format
  • Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • KCD11
  • Full Name
  • Potassium Channel Tetramerization Domain Containing 11
  • Introduction
  • Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as probable substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcription factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state, this effect probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. When knock-down, Hedgehog antagonism is impaired and proliferation of granule cells is sustained. Activates the caspase cascade.
  • Alternative Names
  • Potassium Channel Tetramerization Domain Containing 11; Potassium Channel Tetramerization Domain-Containing Protein 11; Potassium Channel Tetramerisation Domain Containing 11; RING-Type E3 Ubiquitin Transferase Subunit KCTD11; C17orf36; REN; Retinoic Acid, EGF, NGF Induced Gene/Potassium Channel Tetramerization Domain Containing 11; Retinoic Acid, EGF, NGF Induced Gene Protein

Case Studies

Customer reviews and Q&As    

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