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MemDX™ Recombinant Full Length Human AMY3R Protein (Nanodisc, Rho1D4 Tag, FLAG Tag & His10 Tag) (CAT#: SYF-0926-CW38)

Recombinant full-length human AMY3R (CALCR/RAMP3) protein reconstituted in a nanodisc membrane-mimetic system for biochemical, binding, and assay development applications.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • AMY3R (CALCR/RAMP3)
  • Protein Length
  • Full-length
  • Protein Class
  • GPCR
  • Molecular Weight
  • CALCR: 55 kDa; RAMP3: 15 kDa

Product Description

  • Expression Systems
  • Trichoplusia ni insect cells (co-expression)
  • Tag
  • The CALCR construct includes an N-terminal HA signal peptide, FLAG tag, and TEV cleavage site, together with a C-terminal Rho1D4 tag. The RAMP3 construct includes an N-terminal HA signal peptide and His10 tag.
  • Protein Format
  • Nanodisc
  • Purity
  • The protein purity is greater than 90% as determined by SDS-PAGE.

Target

  • Target Protein
  • AMY3R (CALCR/RAMP3)
  • Full Name
  • CALCR: calcitonin receptor; RAMP3: receptor activity modifying protein 3
  • Introduction
  • Amylin 3 receptor (AMY3R (CALCR/RAMP3)) is a full-length human gpcr. Amylin receptor 3's function is to mediate the effects of the hormone amylin on glucose metabolism and appetite suppression, playing a significant role in regulating postprandial blood sugar levels and promoting satiety. The protein is supplied in an MSP-free, copolymer-stabilized native-lipid nanodisc. The preparation uses 3-step purification.
  • Alternative Names
  • CALCR: CTR, CT-R

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