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NativeExtract™ Recombinant Full Length Human CACB4 Protein (Nanodisc, FLAG- & Strep-tagged) (CAT#: SYF-0426-CW83)

This product is recombinant Human CACB4 protein in native nanodisc form. The synthetic compound we developed can solubilize the CACB4 protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • CACB4
  • Protein Length
  • Full length
  • Protein Class
  • Ion Channel
  • Molecular Weight
  • 58.2 kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • The recombinant protein is constructed with FLAG Tag & Strep Tag at C-terminus.
  • Protein Format
  • Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • CACB4
  • Full Name
  • Calcium Voltage-Gated Channel Auxiliary Subunit Beta 4
  • Introduction
  • This gene encodes a member of the beta subunit family of voltage-dependent calcium channel complex proteins. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein encoded by this locus plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE), juvenile myoclonic epilepsy (JME), and episodic ataxia, type 5.
  • Alternative Names
  • Calcium Voltage-Gated Channel Auxiliary Subunit Beta 4; Calcium Channel Voltage-Dependent Subunit Beta 4; CACNLB4; CAB4; Dihydropyridine-Sensitive L-Type, Calcium Channel Beta-4 Subunit; Voltage-Dependent L-Type Calcium Channel Subunit Beta-4; Calcium Channel, Voltage-Dependent, Beta 4 Subunit

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