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NativeExtract™ Recombinant Full Length Human CLCN3 Protein (Nanodisc, FLAG- & Strep-tagged) (CAT#: SYF-0426-CW114)

Datasheet
This product is recombinant Human CLCN3 protein in native nanodisc form. The synthetic compound we developed can solubilize the CLCN3 protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • CLCN3
  • Protein Length
  • Full length
  • Protein Class
  • Ion Channel
  • Molecular Weight
  • 91 kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • The recombinant protein is constructed with FLAG Tag & Strep Tag at C-terminus.
  • Protein Format
  • Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • CLCN3
  • Full Name
  • Chloride Voltage-Gated Channel 3
  • Introduction
  • This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
  • Alternative Names
  • Chloride Voltage-Gated Channel 3; Chloride Channel, Voltage-Sensitive 3; Chloride Channel Protein 3; Chloride Transporter ClC-3; Chloride Channel 3; ClC-3; H(+)/Cl(-) Exchange Transporter 3; CLC3

Case Studies

Customer reviews and Q&As    

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