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NativeExtract™ Recombinant Full Length Human P2RX1 Protein (Nanodisc, FLAG- & Strep-tagged) (CAT#: SYF-0426-CW106)

Datasheet
This product is recombinant Human P2RX1 protein in native nanodisc form. The synthetic compound we developed can solubilize the P2RX1 protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • P2RX1
  • Protein Length
  • Full length
  • Protein Class
  • Ion Channel
  • Molecular Weight
  • 45 kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • The recombinant protein is constructed with FLAG Tag & Strep Tag at C-terminus.
  • Protein Format
  • Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • P2RX1
  • Full Name
  • Purinergic Receptor P2X 1
  • Introduction
  • The protein encoded by this gene belongs to the P2X family of G-protein-coupled receptors. These proteins can form homo-and heterotimers and function as ATP-gated ion channels and mediate rapid and selective permeability to cations. This protein is primarily localized to smooth muscle where binds ATP and mediates synaptic transmission between neurons and from neurons to smooth muscle and may being responsible for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. This protein may also be involved in promoting apoptosis. P2RX1 (Purinergic Receptor P2X 1) is a Protein Coding gene. Diseases associated with P2RX1 include Bleeding Disorder, Platelet-Type, 8 and Neurogenic Bladder. Among its related pathways are Platelet homeostasis and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include ion channel activity and calcium channel activity. An important paralog of this gene is P2RX4. Ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Seems to be linked to apoptosis, by increasing the intracellular concentration of calcium in the presence of ATP, leading to programmed cell death (By similarity).
  • Alternative Names
  • Purinergic Receptor P2X 1; ATP Receptor; P2X1; Purinergic Receptor P2X, Ligand-Gated Ion Channel, 1; Purinergic Receptor P2X, Ligand Gated Ion Channel, 1; Purinergic Receptor P2X1

Case Studies

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