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MemDX™ Recombinant Full Length Human DRD1 Protein (Nanodisc, Rho1D4 Tag & FLAG Tag) (CAT#: SYF-0926-CW113)

Recombinant full-length human DRD1 protein reconstituted in a nanodisc membrane-mimetic system for biochemical, binding, and assay development applications.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • DRD1
  • Protein Length
  • Full-length
  • Protein Class
  • GPCR
  • Molecular Weight
  • 52 kDa
  • Sequence
  • MKTIIALSYIFCLVFADYKDDDDKENLYFQGRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPTGSSGTETSQVAPA

Product Description

  • Expression Systems
  • Trichoplusia ni insect cells
  • Tag
  • The construct includes an N-terminal HA signal peptide, FLAG tag, and TEV cleavage site, together with a C-terminal Rho1D4 tag.
  • Protein Format
  • Nanodisc
  • Purity
  • The protein purity is greater than 90% as determined by SDS-PAGE.

Target

  • Target Protein
  • DRD1
  • Full Name
  • dopamine receptor D1
  • Introduction
  • D(1) dopamine receptor (DRD1) is a full-length human gpcr. The Dopamine Receptor D1 (DRD1) mediates essential functions in motor control, reward, and cognition by stimulating cAMP production in the brain. Its therapeutic relevance lies in managing Parkinson's disease and cognitive impairment, where selective targeting helps restore neurological balance with fewer side effects than non-selective treatments. The protein is supplied in an MSP-free, copolymer-stabilized native-lipid nanodisc. The preparation uses 2-step purification.
  • Alternative Names
  • D1R

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