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MemDX™ Recombinant Full Length Human DRD2 Protein (Biotinylated Nanodisc, Rho1D4 Tag) (CAT#: SYF-0926-CW116)

Recombinant full-length human DRD2 protein reconstituted in a biotinylated nanodisc membrane-mimetic system for immobilization, binding, detection, and assay development applications; the copolymer is biotinylated while the protein itself remains unmodified.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • DRD2
  • Protein Length
  • Full-length
  • Protein Class
  • GPCR
  • Molecular Weight
  • 51 kDa
  • Sequence
  • MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC

Product Description

  • Expression Systems
  • Trichoplusia ni insect cells
  • Tag
  • The construct includes a C-terminal Rho1D4 tag. The copolymer is biotinylated; the protein itself is unmodified.
  • Protein Format
  • Nanodisc
  • Purity
  • The protein purity is greater than 90% as determined by SDS-PAGE.

Target

  • Target Protein
  • DRD2
  • Full Name
  • dopamine receptor D2
  • Introduction
  • D(2) dopamine receptor (DRD2) is a full-length human gpcr. D(2) dopamine receptoris a G-protein coupled receptor inhibits adenylyl cyclase activity and is involved in reward-mediating mesocorticolimbic pathways. DRD2 has been also associated with schizophrenia and moreover it is the main receptor for many antipsychotic drugs. The surrounding nanodisc copolymer is biotinylated to support direct surface immobilization without modifying the protein itself. The preparation uses 2-step purification.
  • Alternative Names
  • D2R

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