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MemDX™ Recombinant Full Length Human ABCG2 Protein (Biotinylated Nanodisc, Rho1D4 Tag) (CAT#: SYF-0926-CW30)

Datasheet
Recombinant full-length human ABCG2 protein reconstituted in a biotinylated nanodisc membrane-mimetic system for immobilization, binding, detection, and assay development applications; the copolymer is biotinylated while the protein itself remains unmodified.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • ABCG2
  • Protein Length
  • Full-length
  • Protein Class
  • ABC Transporter
  • Molecular Weight
  • 72 kDa (homodimer)
  • Sequence
  • MSSSNVEVFIPVSQGNTNGFPATASNDLKAFTEGAVLSFHNICYRVKLKSGFLPCRKPVEKEILSNINGIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANFKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADFFLDIINGDSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKETKAELHQLSGGEKKKKITVFKEISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVIGAIYFGLKNDSTGIQNRAGVLFFLTTNQCFSSVSAVELFVVEKKLFIHEYISGYYRVSSYFLGKLLSDLLPMRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIAAGQSVVSVATLLMTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGFTALQHNEFLGQNFCPGLNATGNNPCNYATCTGEEYLVKQGIDLSPWGLWKNHVALACMIVIFLTIAYLKLLFLKKYS

Product Description

  • Expression Systems
  • HEK293 cells
  • Tag
  • The construct includes a C-terminal Rho1D4 tag. The copolymer is biotinylated; the protein itself is unmodified.
  • Protein Format
  • Nanodisc
  • Purity
  • The protein purity is greater than 90% as determined by SDS-PAGE.

Target

  • Target Protein
  • ABCG2
  • Full Name
  • ATP binding cassette subfamily G member 2
  • Introduction
  • Broad substrate specificity ATP-binding cassette transporter (ABCG2) is a full-length human abc transporter. The ATP-binding cassette transporter ABCG2 is an ATP-binding cassette efflux transporter that plays a critical role in the cellular uptake and elimination of drugs, thereby contributing to their pharmacokinetics. It facilitates the export of chemotherapeutic drugs from various organs and tissues, thus regulating their accumulation and subsequent elimination from the body. Additionally, ABCG2 contributes to the release of urate, an antioxidant present in the bloodstream, into the urine in the intestines. Genetic defects in ABCG2 have been associated with the development of gout. The surrounding nanodisc copolymer is biotinylated to support direct surface immobilization without modifying the protein itself. The preparation uses 2-step purification.
  • Alternative Names
  • EST157481, MXR, BCRP, ABCP, CD338

Case Studies

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