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NativeExtract™ Recombinant Full Length Human GBRA4 Protein (Nanodisc, FLAG- & Strep-tagged) (CAT#: SYF-0426-CW221)

This product is recombinant Human GBRA4 protein in native nanodisc form. The synthetic compound we developed can solubilize the GBRA4 protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • GBRA4
  • Protein Length
  • Full length
  • Protein Class
  • Ion Channel
  • Molecular Weight
  • 61.6 kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • The recombinant protein is constructed with FLAG Tag & Strep Tag at C-terminus.
  • Protein Format
  • Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • GBRA4
  • Full Name
  • Gamma-Aminobutyric Acid Type A Receptor Alpha4 Subunit
  • Introduction
  • Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. This gene encodes subunit alpha-4, which is involved in the etiology of autism and eventually increases autism risk through interaction with another subunit, gamma-aminobutyric acid receptor beta-1 (GABRB1). Alternatively spliced transcript variants encoding different isoforms have been found in this gene.
  • Alternative Names
  • Gamma-Aminobutyric Acid Type A Receptor Alpha4 Subunit; Gamma-Aminobutyric Acid (GABA) A Receptor, Alpha 4; GABA(A) Receptor Subunit Alpha-4; GABA(A) Receptor, Alpha 4

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