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NativeExtract™ Recombinant Full Length Human CLDN18.2 Protein (Petitide Nanodisc, FLAG- & Strep-tagged) (CAT#: SYF-0426-CW310)

Datasheet
This product is recombinant full length Human CLDN18.2 protein in peptide nanodisc form. The synthetic peptide scaffold we developed can extract and stabilize the CLDN18.2 protein while preserving its native conformation.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • CLDN18.2
  • Protein Length
  • Full length
  • Protein Class
  • Transporter
  • Molecular Weight
  • 27.5 kDa
  • Sequence
  • Our product features full-length membrane proteins with complete, native sequences, ensuring optimal structural integrity and functional activity for your research needs.

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • The recombinant protein is constructed with FLAG Tag & Strep Tag at C-terminus.
  • Protein Format
  • Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • CLDN18.2
  • Full Name
  • claudin 18
  • Introduction
  • Claudin-18 (CLDN18), a member of the claudin family, is a four-pass transmembrane protein with two extracellular loops and cytoplasmic N- and C-tails, found in tight junctions. CLDN18 regulates paracellular permeability, cell polarity, and signaling. Deficiency in CLDN18 has been linked to conditions such as atrophic gastritis, spasmolytic polypeptide-expressing metaplasia (SPEM), and asthma. The lung-specific isoform, CLDN18.1, influences alveolar epithelial type II (AT2) cell proliferation and organ size. Restoring CLDN18.1 expression in human lung cancer cells has been shown to suppress proliferation by inhibiting the IGF-1R/AKT signaling axis. While CLDN18 is not expressed in other healthy tissues, the gastric mucosa-specific isoform, CLDN18.2, is highly expressed in primary gastric cancers. CLDN18.2, present on the surface of epithelial tumor cells, is a promising target for antibody and CAR-T therapies currently under development.
  • Alternative Names
  • SFTA5; SFTPJ

Case Studies

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