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MemDX™ Recombinant Full Length Human GLP1R Protein (Biotinylated Nanodisc, Rho1D4 Tag & His10 Tag) (CAT#: SYF-0926-CW128)

Datasheet
Recombinant full-length human GLP1R protein reconstituted in a biotinylated nanodisc membrane-mimetic system for immobilization, binding, detection, and assay development applications; the copolymer is biotinylated while the protein itself remains unmodified.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • GLP1R
  • Protein Length
  • Full-length
  • Protein Class
  • GPCR
  • Molecular Weight
  • 51 kDa
  • Sequence
  • RPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS

Product Description

  • Expression Systems
  • Trichoplusia ni insect cells
  • Tag
  • The construct includes an HA signal peptide and a C-terminal His10-HRV 3C-Rho1D4 fusion tag. The copolymer is biotinylated; the protein itself is unmodified.
  • Protein Format
  • Nanodisc
  • Purity
  • The protein purity is greater than 90% as determined by SDS-PAGE.

Target

  • Target Protein
  • GLP1R
  • Full Name
  • glucagon like peptide 1 receptor
  • Introduction
  • Glucagon-like peptide 1 receptor (GLP1R) is a full-length human gpcr. G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a role in regulating insulin secretion in response to GLP-1. The surrounding nanodisc copolymer is biotinylated to support direct surface immobilization without modifying the protein itself. The preparation uses 2-step purification.
  • Alternative Names
  • GLP-1R

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