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NativeExtract™ Biotinylated Recombiant Human PTGER4 Membrane Protein (Full length, Super Nanodisc) (CAT#: SYF-0826-CW31)

This product is a biotinylated recombinant Human PTGER4 protein in native nanodisc form. The synthetic compound we developed can solubilize the PTGER4 protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • PTGER4
  • Protein Length
  • Full length
  • Protein Class
  • GPCR
  • Molecular Weight
  • 53.1kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • C-terminal FLAG & Avi Tag
  • Protein Format
  • Nanodisc
  • Reconstitution
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • PTGER4
  • Full Name
  • Prostaglandin E receptor 4
  • Introduction
  • This protein is a member of the G protein-coupled receptor (GPCR) family and functions as one of the four receptors for prostaglandin E2 (PGE2). Upon activation, it participates in multiple downstream signaling pathways, including T-cell factor signaling, induction of early growth response 1 (EGR1) expression, regulation of cyclooxygenase-2 (COX-2) mRNA stability, and phosphorylation of glycogen synthase kinase-3 (GSK-3). Studies in knockout mouse models suggest that this receptor is involved in diverse physiological processes, including neonatal adaptation of the circulatory system, bone homeostasis, and the initiation of cutaneous immune responses.
  • Alternative Names
  • EP4; EP4R; prostaglandin E2 receptor EP4 subtype; PGE receptor, EP4 subtype; PGE2 receptor EP4 subtype; prostaglandin E receptor 4 (subtype EP4); prostanoid EP4 receptor; PTGER4; Prostaglandin E receptor 4

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