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NativeExtract™ Recombinant Full Length Human GRIA4 Protein (Nanodisc, FLAG- & Strep-tagged) (CAT#: SYF-0426-CW122)

Datasheet
This product is recombinant Human GRIA4 protein in native nanodisc form. The synthetic compound we developed can solubilize the GRIA4 protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • GRIA4
  • Protein Length
  • Full length
  • Protein Class
  • Ion Channel
  • Molecular Weight
  • 100.9 kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • The recombinant protein is constructed with FLAG Tag & Strep Tag at C-terminus.
  • Protein Format
  • Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • GRIA4
  • Full Name
  • Glutamate Ionotropic Receptor AMPA Type Subunit 4
  • Introduction
  • Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia.
  • Alternative Names
  • Glutamate Ionotropic Receptor AMPA Type Subunit 4; Glutamate Receptor, Ionotrophic, AMPA 4; AMPA-Selective Glutamate Receptor 4; GluR-4; GluR-D; GLUR4; GluA4

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