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NativeExtract™ Recombinant Full Length Human 5HT3A Protein (Nanodisc, FLAG- & Strep-tagged) (CAT#: SYF-0426-CW172)

This product is recombinant Human 5HT3A protein in native nanodisc form. The synthetic compound we developed can solubilize the 5HT3A protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • 5HT3A
  • Protein Length
  • Full length
  • Protein Class
  • Ion Channel
  • Molecular Weight
  • 55.3 kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • The recombinant protein is constructed with FLAG Tag & Strep Tag at C-terminus.
  • Protein Format
  • Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • 5HT3A
  • Full Name
  • 5-Hydroxytryptamine Receptor 3A
  • Introduction
  • The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified.
  • Alternative Names
  • 5-Hydroxytryptamine Receptor 3A; 5-Hydroxytryptamine (Serotonin) Receptor 3A, Ionotropic; Serotonin-Gated Ion Channel Receptor; 5-Hydroxytryptamine Receptor 3; Serotonin Receptor 3A; 5-HT3-A; 5-HT-3

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