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NativeExtract™ Recombinant Full Length Human CCR8 Protein (Petitide Nanodisc, FLAG- & Strep-tagged) (CAT#: SYF-0426-CW307)

Datasheet
This product is recombinant Human CCR8 protein in peptide nanodisc form. The synthetic peptide scaffold we developed can solubilize the CCR8 protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • CCR8
  • Protein Length
  • Full length
  • Protein Class
  • GPCR; Checkpoint
  • Molecular Weight
  • 40.7 kDa
  • Sequence
  • Our product features full-length membrane proteins with complete, native sequences, ensuring optimal structural integrity and functional activity for your research needs.

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • The recombinant protein is constructed with FLAG Tag & Strep Tag at C-terminus.
  • Protein Format
  • Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • CCR8
  • Full Name
  • C-C motif chemokine receptor 8
  • Introduction
  • CCR8 is a member of the beta chemokine receptor family and is predicted to be a seven-transmembrane protein, similar to G protein-coupled receptors. Chemokines and their receptors play a crucial role in the migration of various cell types to inflammatory sites. This receptor is predominantly expressed in the thymus. Ligands such as I-309, thymus activation-regulated cytokine (TARC), and macrophage inflammatory protein-1 beta (MIP-1 beta) have been identified for this receptor. Research suggests its involvement in regulating monocyte chemotaxis and thymic cell apoptosis. More specifically, it may aid in positioning activated T cells at sites of antigenic challenge and within specialized regions of lymphoid tissues. The gene for this receptor is located within the chemokine receptor gene cluster region.
  • Alternative Names
  • CY6; TER1; CCR-8; CKRL1; CDw198; CMKBR8; GPRCY6; CMKBRL2; CC-CKR-8

Case Studies

Customer reviews and Q&As    

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